富黄酮类化合物芙蓉叶提取物对链脲佐菌素致大鼠睾丸损伤的保护作用

Q3 Pharmacology, Toxicology and Pharmaceutics

Phytomedicine Plus Pub Date : 2025-05-01 DOI:10.1016/j.phyplu.2025.100808

Basiru Olaitan Ajiboye , Courage Dele Famusiwa , John Adeolu Falode , Daniel Okwukwe Akojuru , Bamikole Tosin Owolabi , Adedeji A. Adejumo , Babatunji Emmanuel Oyinloye , Olawale Razaq Ajuwon , Oluwatosin Olalekan Ogedengbe , Oluwafemi Adeleke Ojo

{"title":"富黄酮类化合物芙蓉叶提取物对链脲佐菌素致大鼠睾丸损伤的保护作用","authors":"Basiru Olaitan Ajiboye , Courage Dele Famusiwa , John Adeolu Falode , Daniel Okwukwe Akojuru , Bamikole Tosin Owolabi , Adedeji A. Adejumo , Babatunji Emmanuel Oyinloye , Olawale Razaq Ajuwon , Oluwatosin Olalekan Ogedengbe , Oluwafemi Adeleke Ojo","doi":"10.1016/j.phyplu.2025.100808","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the protective effects of flavonoid-rich extracts from <em>Hibiscus sabdariffa</em> leaves on testicular cumulative reproductive function biomarkers in streptozotocin (STZ)-induced diabetic rats.</div></div><div><h3>Methods</h3><div>Rats were induced with 40 mg/kg body weight (bwt) STZ intraperitoneally (i.p.), after which they were administered either a low (150 mg/kg bwt) or a high (300 mg/kg bwt) dose of flavonoid-rich extracts from <em>H. sabdariffa</em> leaves. Testicular redox biomarkers, reproductive hormone biomarkers, and relative gene expression levels of PDE-5 and iNOS were assessed. Additionally, histological data, glucose levels, G6PDH activity, and hydroxysteroid dehydrogenase activities (3β-HSD and 17β-HSD) were analyzed.</div></div><div><h3>Results</h3><div><em>H. sabdariffa</em> leaf extract was promising for restoring redox balance, normalizing reproductive hormone levels, modulating gene expression, and regulating various biochemical parameters related to testicular function.</div></div><div><h3>Conclusion</h3><div>These data suggest a potential therapeutic role of <em>H. sabdariffa</em> leaves in mitigating the testicular dysfunction associated with diabetes.</div></div>","PeriodicalId":34599,"journal":{"name":"Phytomedicine Plus","volume":"5 2","pages":"Article 100808"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on streptozotocin-induced testicular damage in rats\",\"authors\":\"Basiru Olaitan Ajiboye , Courage Dele Famusiwa , John Adeolu Falode , Daniel Okwukwe Akojuru , Bamikole Tosin Owolabi , Adedeji A. Adejumo , Babatunji Emmanuel Oyinloye , Olawale Razaq Ajuwon , Oluwatosin Olalekan Ogedengbe , Oluwafemi Adeleke Ojo\",\"doi\":\"10.1016/j.phyplu.2025.100808\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>This study investigated the protective effects of flavonoid-rich extracts from <em>Hibiscus sabdariffa</em> leaves on testicular cumulative reproductive function biomarkers in streptozotocin (STZ)-induced diabetic rats.</div></div><div><h3>Methods</h3><div>Rats were induced with 40 mg/kg body weight (bwt) STZ intraperitoneally (i.p.), after which they were administered either a low (150 mg/kg bwt) or a high (300 mg/kg bwt) dose of flavonoid-rich extracts from <em>H. sabdariffa</em> leaves. Testicular redox biomarkers, reproductive hormone biomarkers, and relative gene expression levels of PDE-5 and iNOS were assessed. Additionally, histological data, glucose levels, G6PDH activity, and hydroxysteroid dehydrogenase activities (3β-HSD and 17β-HSD) were analyzed.</div></div><div><h3>Results</h3><div><em>H. sabdariffa</em> leaf extract was promising for restoring redox balance, normalizing reproductive hormone levels, modulating gene expression, and regulating various biochemical parameters related to testicular function.</div></div><div><h3>Conclusion</h3><div>These data suggest a potential therapeutic role of <em>H. sabdariffa</em> leaves in mitigating the testicular dysfunction associated with diabetes.</div></div>\",\"PeriodicalId\":34599,\"journal\":{\"name\":\"Phytomedicine Plus\",\"volume\":\"5 2\",\"pages\":\"Article 100808\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytomedicine Plus\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667031325000806\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytomedicine Plus","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667031325000806","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

摘要

目的探讨富黄酮提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠睾丸累积生殖功能生物标志物的保护作用。方法用40 mg/kg体重（bwt）的STZ腹腔诱导大鼠，然后分别给予低剂量（150 mg/kg bwt）和高剂量（300 mg/kg bwt）的富黄酮提取物。评估睾丸氧化还原生物标志物、生殖激素生物标志物以及PDE-5和iNOS的相对基因表达水平。此外，还分析了组织学数据、葡萄糖水平、G6PDH活性和羟基类固醇脱氢酶活性（3β-HSD和17β-HSD）。菝葜叶提取物具有恢复氧化还原平衡、调节生殖激素水平、调节基因表达和调节睾丸功能相关的各种生化参数的作用。结论丹参叶对糖尿病患者睾丸功能障碍有潜在的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on streptozotocin-induced testicular damage in rats

查看原文本刊更多论文

Protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on streptozotocin-induced testicular damage in rats

Objective

This study investigated the protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on testicular cumulative reproductive function biomarkers in streptozotocin (STZ)-induced diabetic rats.

Methods

Rats were induced with 40 mg/kg body weight (bwt) STZ intraperitoneally (i.p.), after which they were administered either a low (150 mg/kg bwt) or a high (300 mg/kg bwt) dose of flavonoid-rich extracts from H. sabdariffa leaves. Testicular redox biomarkers, reproductive hormone biomarkers, and relative gene expression levels of PDE-5 and iNOS were assessed. Additionally, histological data, glucose levels, G6PDH activity, and hydroxysteroid dehydrogenase activities (3β-HSD and 17β-HSD) were analyzed.

Results

H. sabdariffa leaf extract was promising for restoring redox balance, normalizing reproductive hormone levels, modulating gene expression, and regulating various biochemical parameters related to testicular function.