Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection

Glucose is the main source of energy in cellular metabolism and is essential for normal cellular function and growth. Abnormal glucose levels can lead to significant health issues, highlighting the importance of developing efficient, accessible, and precise glucose detection platform. Here, the Ti₃C₂T_x@Pt nanocomposites were developed with uniformly dispersed Pt nanoparticles using a simple self-reduction method, effectively addressing the tendency of pure metal nanoparticles to aggregate. The Ti₃C₂T_x@Pt nanocomposite demonstrated excellent peroxidase like activity and electrocatalytic property, enabling the development of a dual-mode detection platform for glucose that integrated both colorimetric and electrochemical sensing. The colorimetric biosensor demonstrated a linear detection range of 0.5–10 mM with a limit of detection (LOD) 1.37 μM, while the electrochemical biosensor exhibited a linear range of 0.01–11.7 mM with the detection limit of 7.4 μM. This dual-mode platform offered a simple, sensitive, and visualized approach for glucose detection, with broad potential for application in biomedical and clinical diagnostics.