Bin-Kai Liu, Kun-Xu Teng, Li-Ya Niu and Qing-Zheng Yang*,
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BODIPY-Based Photosensitizer with Outstanding Photocytotoxicity for Deep-Tissue Photodynamic Therapy
Tissue penetration and hypoxia present significant challenges for photodynamic therapy (PDT), restricting its clinical utility. We here report a Type-I photosensitizer (OBDP) with outstanding photocytotoxicity to overcome these limitations for deep-tissue PDT. OBDP targets lipid droplets in cancer cells. Upon irradiation, OBDP oxidizes nearby polyunsaturated fatty acids (PUFAs) into hydroperoxides through a photoinduced electron transfer mechanism, ultimately evoking ferroptosis. Under ultralow-power light-irradiation (660 nm, 5 mW cm–2, 3 J cm–2), OBDP effectively kills cancer cells, displaying an impressively low half-maximal inhibitory concentration (IC50) of 55.5–76.3 nM for three cancer cell lines (HeLa, A549, and HepG2 cells) under hypoxic conditions (2% O2). Due to the outstanding photocytotoxicity, OBDP can efficiently ablate tumors in deep-tissue PDT model experiments, achieving a tumor growth inhibition rate of up to 88.1%. This work represents a significant advancement in PDT and offers valuable insights for the development of photosensitizers tailored for deep-tissue solid tumors.
期刊介绍：
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.
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