中国海参中蟾二烯内酯类及其化学分类意义

IF 2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Systematics and Ecology Pub Date : 2025-05-03 DOI:10.1016/j.bse.2025.105034

Fengying Yang , Mengjia Liu , Shan Xie, Rongxian Li, Han Xue, Xianshou Zhao, Wenying Yin, Na Liu

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引用次数: 0

摘要

从毛茛科（Helleborus thibetanus）粗乙醇提取物的正丁醇可溶部分中分离出一个新的丁二烯内酯(1)和10个已知的丁二烯内酯（2-11）。新化合物的结构是通过分析光谱数据确定的，包括HRESIMS和1D和2D NMR。大多数化合物对MDA-MB-231乳腺癌细胞具有显著的细胞毒性，IC50值在0.0007 ~ 2.586 μM之间。其中化合物1、6、7为首次在毛茛科植物中发现。此外，还对分离化合物的化学分类意义进行了全面探讨。

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Bufadienolides from Helleborus thibetanus Franch and their chemotaxonomic significance

A new bufadienolide (1), along with ten known bufadienolides (2–11), were isolated from the n-butanol soluble fraction of the crude ethanol extract of Helleborus thibetanus (Ranunculaceae). The structure of the new compound was determined by the analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR. Most of the compounds exhibited remarkable significant cytotoxicity against MDA-MB-231 breast cancer cells, with IC₅₀ values ranging from 0.0007 to 2.586 μM. Notably, compounds 1, 6, and 7 were discovered to exist within the Ranunculaceae family for the first time. Additionally, the chemotaxonomic significance of the isolated compounds was comprehensively explored.

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来源期刊

Biochemical Systematics and Ecology 生物-进化生物学

CiteScore

3.00

自引率

12.50%

发文量

147

审稿时长

43 days

期刊介绍： Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology). In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.