Construction of Light and Temperature-Responsive Acrylamide Copolymer-Metal Organic Frameworks for Breast Cancer Therapy

Breast cancer is a common and increasingly prevalent female tumor. Current treatments include surgery, radiation, and drug therapy, but these often result in high recurrence rates and significant side effects. Thus, developing new therapeutic drugs for breast cancer remains a clinical priority. We synthesized an intelligent drug delivery system, polyacrylamide-polypyrrole (PAM-PPy), through radical copolymerization and combined it with CP1@1 to construct a light and heat-responsive drug delivery platform. The synthesized PAM-PPy@CP1@1 was characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (FESEM), and Thermogravimetric Analysis (TG). This designed system was used to load the newly synthesized compound 1. When compound 1 was encapsulated in PAM-PPy@CP1, its cumulative release reached 67.01% after 6 h of near-infrared (NIR) irradiation at pH 7.4. During the controlled release of compound 1, PAM-PPy acted as a photothermal transducer, converting NIR radiation into heat while maintaining the temperature within its responsive range. Additionally, PAM-PPy functioned as a gatekeeper, preventing the burst release of compound 1. In vitro cell experiments assessed its inhibitory activity on the proliferation of breast cancer cells. Our study provides a platform for developing breast cancer therapeutics.

Graphical Abstract

A photothermal-responsive drug delivery platform, PAM-PPy@CP1@1, was constructed, and the inhibitory activity of the system on the proliferation of breast cancer cells was evaluated using in vitro cellular assays, providing a platform for the development of therapies for breast cancer.