Takveer Singh, Surbhi Dhadda, Shikhar Gupta, Sanketsinh Thakore, Samaksh Goyal, Soumya V Menon, Saleh H. Salmen, Arunachalam Chinnathambi
{"title":"研究锶和铁掺杂tio2 -叶酸纳米复合材料的抗菌、抗氧化和抗癌活性：潜在的治疗应用","authors":"Takveer Singh, Surbhi Dhadda, Shikhar Gupta, Sanketsinh Thakore, Samaksh Goyal, Soumya V Menon, Saleh H. Salmen, Arunachalam Chinnathambi","doi":"10.1007/s10904-024-03421-9","DOIUrl":null,"url":null,"abstract":"<div><p>Nanoscale TiO<sub>2</sub>-based materials are gaining popularity in the healthcare sector due to their antimicrobial properties, low cost, and adaptable physicochemical characteristics. Despite extensive research, their high biological compatibility along with biocidal activities fall short till date. Herein, Sr and Fe ion doped titanium dioxide conjugated with folic acid nanocomposite (TiO<sub>2</sub>SrFeFA) is synthesized and studied for antibacterial, antifungal, and anticancer properties. As-synthesized TiO<sub>2</sub>SrFeFA nanocomposite exhibit spherical morphology with anatase phase, efficiently doped Sr and Fe ion, and embedded in folic acid matrix. TiO<sub>2</sub>SrFeFA shows excellent antibacterial activity against <i>Staphylococcus aureus</i>,<i> Staphylococcus pneumoniae</i>,<i> Bacillus subtilis</i>,<i> Klebsiella pneumoniae</i>,<i> Shigella dysenteriae and Escherichia coli</i>; antifungal activity against <i>Candida albicans</i>; anticancer activity against breast cancer MOLT-4 cell and antioxidant activity. The effectiveness of Sr and Fe ion doped titanium dioxide nanoparticles conjugated with FA demonstrated the nanomaterial’s potential as a biocompatible biocidal agent.</p></div>","PeriodicalId":639,"journal":{"name":"Journal of Inorganic and Organometallic Polymers and Materials","volume":"35 4","pages":"2757 - 2766"},"PeriodicalIF":3.9000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigating the Antimicrobial, Antioxidant and Anticancer Activities of Sr and Fe Doped TiO2-Folic Acid Nanocomposite: Potential Therapeutic Applications\",\"authors\":\"Takveer Singh, Surbhi Dhadda, Shikhar Gupta, Sanketsinh Thakore, Samaksh Goyal, Soumya V Menon, Saleh H. Salmen, Arunachalam Chinnathambi\",\"doi\":\"10.1007/s10904-024-03421-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nanoscale TiO<sub>2</sub>-based materials are gaining popularity in the healthcare sector due to their antimicrobial properties, low cost, and adaptable physicochemical characteristics. Despite extensive research, their high biological compatibility along with biocidal activities fall short till date. Herein, Sr and Fe ion doped titanium dioxide conjugated with folic acid nanocomposite (TiO<sub>2</sub>SrFeFA) is synthesized and studied for antibacterial, antifungal, and anticancer properties. As-synthesized TiO<sub>2</sub>SrFeFA nanocomposite exhibit spherical morphology with anatase phase, efficiently doped Sr and Fe ion, and embedded in folic acid matrix. TiO<sub>2</sub>SrFeFA shows excellent antibacterial activity against <i>Staphylococcus aureus</i>,<i> Staphylococcus pneumoniae</i>,<i> Bacillus subtilis</i>,<i> Klebsiella pneumoniae</i>,<i> Shigella dysenteriae and Escherichia coli</i>; antifungal activity against <i>Candida albicans</i>; anticancer activity against breast cancer MOLT-4 cell and antioxidant activity. The effectiveness of Sr and Fe ion doped titanium dioxide nanoparticles conjugated with FA demonstrated the nanomaterial’s potential as a biocompatible biocidal agent.</p></div>\",\"PeriodicalId\":639,\"journal\":{\"name\":\"Journal of Inorganic and Organometallic Polymers and Materials\",\"volume\":\"35 4\",\"pages\":\"2757 - 2766\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Inorganic and Organometallic Polymers and Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10904-024-03421-9\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inorganic and Organometallic Polymers and Materials","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10904-024-03421-9","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Investigating the Antimicrobial, Antioxidant and Anticancer Activities of Sr and Fe Doped TiO2-Folic Acid Nanocomposite: Potential Therapeutic Applications
Nanoscale TiO2-based materials are gaining popularity in the healthcare sector due to their antimicrobial properties, low cost, and adaptable physicochemical characteristics. Despite extensive research, their high biological compatibility along with biocidal activities fall short till date. Herein, Sr and Fe ion doped titanium dioxide conjugated with folic acid nanocomposite (TiO2SrFeFA) is synthesized and studied for antibacterial, antifungal, and anticancer properties. As-synthesized TiO2SrFeFA nanocomposite exhibit spherical morphology with anatase phase, efficiently doped Sr and Fe ion, and embedded in folic acid matrix. TiO2SrFeFA shows excellent antibacterial activity against Staphylococcus aureus, Staphylococcus pneumoniae, Bacillus subtilis, Klebsiella pneumoniae, Shigella dysenteriae and Escherichia coli; antifungal activity against Candida albicans; anticancer activity against breast cancer MOLT-4 cell and antioxidant activity. The effectiveness of Sr and Fe ion doped titanium dioxide nanoparticles conjugated with FA demonstrated the nanomaterial’s potential as a biocompatible biocidal agent.
期刊介绍：
Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.
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