COVID-19中耳炎伴积液的发病率及预后：病例-对照分析

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2025-04-28 DOI:10.1016/j.amjoto.2025.104649

Qian Yu , Yuedong Zhang , Huina Lu , Yanli Zhao , Xin Zhou

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引用次数: 0

摘要

目的探讨SARS-CoV-2与分泌性中耳炎（OME）的关系，评估中耳液（MEF）中病毒的存在及其对OME发病率和患者预后的影响。方法采用病例对照研究，选取新冠肺炎患者86例，对照组20例。OME发病率在三个时间段进行比较。分析康复率、复发率、置管率、咽鼓管功能障碍问卷-7 （ETDQ-7）评分及听力学结果。结果MEF样品中SARS-CoV-2的检测时间与鼻拭子相似，分别为28.65±8.99天和27.18±7.99天。COVID-19感染后OME的发病率显著增加，特别是在2022年至2013年期间(P <；0.05)。两组患者的治愈率、复发率和置管率均无显著差异(P >；0.05)。治疗干预后ETDQ-7评分保持不变(P >；0.05)。在空气传导阈值和气骨间隙测量上发现有统计学意义的差异(P <；0.05)。结论MEF中SARS-CoV-2的存在与发生OME的风险升高相关，但对其预后的影响很小。

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Incidence and prognosis of otitis media with effusion in COVID-19 patients a comparative case-control analysis

Objective

To investigate the association between SARS-CoV-2 and secretory otitis media (OME), evaluating the presence of the virus in middle ear fluid (MEF) and its impact on OME incidence and patient outcomes.

Methods

A case-control study was conducted with COVID-19 patients (n = 86) and control subjects (n = 20). OME incidence was compared across three time periods. Recovery rates, recurrence rates, catheterization rates, Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7) scores, as well as audiometry results were analyzed.

Results

The detection of SARS-CoV-2 in MEF samples showed a similar duration compared to nasal swabs (28.65 ± 8.99 vs 27.18 ± 7.99 days). There was a significant increase in OME incidence following COVID-19 infection, particularly during the '22-'23 period (P < 0.05). No significant differences were observed in terms of recovery rates, recurrence rates or catheterization rates among groups (P > 0.05). ETDQ-7 scores remained unchanged after treatment intervention (P > 0.05). Statistically significant differences were found for air conduction threshold and air-bone gap measurements (P < 0.05).

Conclusion

The presence of SARS-CoV-2 in MEF is associated with an elevated risk of developing OME but has minimal impact on the prognosis of this condition.

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

期刊介绍： Be fully informed about developments in otology, neurotology, audiology, rhinology, allergy, laryngology, speech science, bronchoesophagology, facial plastic surgery, and head and neck surgery. Featured sections include original contributions, grand rounds, current reviews, case reports and socioeconomics.