利用纳米传输系统来解决宫颈癌治疗的挑战

IF 5.3 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics Pub Date : 2025-04-28 DOI:10.1016/j.ijpharm.2025.125657

Xinyu Wang , Qi Li , Jianxin Liu , Chunbao Xie , Liang Zou , Yi Shi , Lingxi Jiang , Xianyan Qin

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引用次数: 0

摘要

宫颈癌（CC）仍然是妇女中普遍存在的恶性肿瘤，目前的治疗策略在控制其发病率上升方面面临着重大挑战。纳米递送系统已经成为阻碍CC进展的一种很有前途的方法。本文综述了CC的发病机制及其生理特征，并重点介绍了各种纳米递送系统在CC治疗中的应用。具体来说，它强调了内部（如pH值、活性氧、谷胱甘肽）和外部（如光、磁、声波、微波、电）刺激响应的纳米递送平台的潜力，以提高治疗效果。纳米递送系统在CC治疗中的挑战，包括体内稳定性、生物安全性、分布和代谢过程，以及潜在的补救措施。此外，该综述强调了最近用于CC治疗的纳米递送系统的临床前进展。通过深入探索纳米材料的应用，本文综述为推进CC处理和刺激该领域未来的研究和创新提供了有价值的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Harnessing nano-delivery systems to un-cover the challenges for cervical cancer therapy

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Harnessing nano-delivery systems to un-cover the challenges for cervical cancer therapy

Cervical cancer (CC) remains a prevalent malignancy among women, with current therapeutic strategies facing significant challenges in curbing its rising incidence. Nano-delivery systems have emerged as a promising approach to hinder CC progression. This review provides a comprehensive examination of CC pathogenesis and its physiological characteristics while focusing on applying various nano-delivery systems in CC therapy. Specifically, it highlights the potential of both internal (e.g., pH, reactive oxygen species, glutathione) and external (e.g., Photo, magnetism, sound waves, microwaves, electricity) stimuli-responsive nano-delivery platforms to enhance therapeutic efficacy. The challenges of nano-delivery systems in CC therapy, encompassing in vivo stability, biosafety, distribution, and metabolic processes, are addressed, along with potential remedies. Additionally, the review underscores recent preclinical advances in nano-delivery systems for CC therapy. By thoroughly exploring nanomaterial applications, this review provides valuable perspectives for advancing CC treatment and stimulating future research and innovation in this domain.

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来源期刊

International Journal of Pharmaceutics 医学-药学

CiteScore

10.70

自引率

8.60%

发文量

951

审稿时长

72 days

期刊介绍： The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.