从乌头内生真菌扩张青霉中提取的一种新型吲哚类生物碱-麦角甾缀合物

IF 4.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

RSC Advances Pub Date : 2025-05-02 DOI:10.1039/D5RA02287H

Chenzhe Li, Ziruo He, Zhaofei Wen, Guangqian Sun, Xianying Tang, Tianpeng Yin and Le Cai

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引用次数: 0

摘要

从著名中药乌头乌头中分离得到内生真菌扩张青霉WTJP1。对这种乌头衍生真菌的化学研究导致了一种先前未描述的化合物的分离，膨胀素(1)，它代表了自然界中发现的吲哚生物碱-麦角甾缀合物的第一个例子。通过广泛的光谱和光谱ECD和DP4+概率分析确定了1的结构归属。此外，化合物1对5种人类癌细胞的细胞毒活性进行了评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Expansinine, a novel indole alkaloid–ergosteroid conjugate from the endophytic fungus Penicillium expansum of Aconitum carmichaelii†

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Expansinine, a novel indole alkaloid–ergosteroid conjugate from the endophytic fungus Penicillium expansum of Aconitum carmichaelii†

The endophytic fungus Penicillium expansum WTJP1 was isolated from Aconitum carmichaelii Debeaux, a famous traditional Chinese medicine known as aconite. Chemical investigation of this aconite-derived fungus led to the isolation of one previously undescribed compound, expansinine (1), which represents the first example of an indole alkaloid–ergosteroid conjugate found in nature. The assignments of the structure of 1 were determined by extensive spectroscopic and spectrometric ECD and DP4+ probability analyses. In addition, compound 1 was evaluated for its cytotoxic activities against five human cancer cell lines.

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来源期刊

RSC Advances chemical sciences-

CiteScore

7.50

自引率

2.60%

发文量

3116

审稿时长

1.6 months

期刊介绍： An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.