离子选择性相互作用引发的药物传递系统研究

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-09 DOI:10.1039/d5cc00636h

Dorota Buczyńska , Emilia Stelmach , Justyna Kalisz , Bohdan Paterczyk , Piotr Piątek , Krzysztof Maksymiuk , Agata Michalska

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引用次数: 0

摘要

提出了一种药物递送系统，允许药物从亲脂性聚合物中释放，以响应与溶液中存在的触发离子的离子选择性相互作用。触发离子自发和化学计量结合到聚合物相是由它们与不带电的离子载体的优先结合驱动的，导致带电的药物离子被释放以保持电中性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Towards drug delivery systems triggered by ion-selective interactions†

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Towards drug delivery systems triggered by ion-selective interactions†

A drug delivery system is proposed that allows the release of a drug from a lipophilic polymer in response to ion-selective interactions with trigger ions present in solution. Spontaneous and stoichiometric incorporation of the trigger ions into a polymer phase is driven by their preferential binding to an uncharged ionophore resulting in charged drug ions being released to preserve electroneutrality.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.