用于肝细胞癌的电化学生物传感器

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-04-24 DOI:10.1016/j.cca.2025.120328

Lei Wang , Jianjiang Pan , Bita Badehnoosh

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引用次数: 0

摘要

本文综述了肝细胞癌生物特征的电化学检测技术的研究进展，强调了其在提高肝细胞癌的及时检测和管理方面的潜力。在这项研究中，作者探讨了肝癌生物标记的现状，包括传统的蛋白质，如甲胎蛋白和有前途的生物标记，如非编码rna和循环肿瘤DNA （ctDNA）。本文分析了电化学生物传感的原理，并探讨了采用表面改性技术、创新识别元素和纳米材料的复杂传感器设计。特别关注的是基于适配体的传感器，微流体技术和无标签方法。本文讨论了在提高灵敏度和特异性方面的最新进展，其中一些平台在飞图尺度上达到了阈值。讨论还包括在护理点应用方面取得的进展以及在将实验范式过渡到医疗应用方面面临的障碍。目前正在评估这些方法对医疗结果的预期影响，强调早期发现和量身定制的治疗方法。未来的研究应侧重于创造先进的、集成的检测系统，并进行全面的临床验证研究，以评估电化学生物传感器在现实世界中的有效性。

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Electrochemical biosensors for hepatocellular carcinoma

The current review analyzes progress in electrochemical detection techniques for hepatocellular carcinoma biosignatures, highlighting their potential to enhance the timely detection and management of hepatocellular carcinoma. In this study, the authors explore the present state of hepatocellular carcinoma biosignatures, encompassing conventional proteins such as alpha-fetoprotein and promising biosignatures like non-coding RNAs and circulatory tumor DNA (ctDNA). This text analyzes the principles of electrochemical biosensing and explores sophisticated sensor designs employing surface modification techniques, innovative recognition elements, and nanomaterials. Particular focus is directed towards aptamer-based sensors, microfluidic technologies, and label-free methodologies. Herein, recent advancements in enhancing sensitivity and specificity are discussed, with some platforms reaching a threshold at the femtogram scale. The discussion also encompasses the progress achieved in point-of-care applications and the obstacles faced in transitioning experimental paradigms to medical applications. The prospective influence of these methodologies on medical results is under evaluation, emphasizing early detection and tailored treatment approaches. Future research should focus on creating advanced, integrated detection systems and conducting comprehensive clinical validation studies to assess the real-world effectiveness of electrochemical biosensors.

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.