可见光介导的n -芳基丙酰胺的无氧化剂串联酰基甲基化/ipso-螺旋环化：获得3-酰基甲基azspiro[4,5]三烯酮

IF 3.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Molecular Catalysis Pub Date : 2025-05-02 DOI:10.1016/j.mcat.2025.115120

Binfeng Zhu , Guokai Li , Mingzhu Li , Deyu Bao , Jingchao Chen , Devendar Ponnam , Baomin Fan

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引用次数: 0

摘要

研究了一种新的可见光介导的N-（对甲氧基）丙酰胺与α -溴酮的酰基甲基化/异螺旋环化反应，从而高效合成了多种具有高选择性的3-酰基甲基功能化氮杂螺[4,5]三烯酮。该方法通过自由基C-Br键裂解、异旋生成和脱芳化等一系列反应构建了两个新的C-C键。该反应操作简单，可扩展，底物范围广，具有良好的官能团耐受性，易于获得3-酰基甲基氮杂螺[4,5]三烯酮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-light-mediated oxidant-free tandem acylmethylation/ipso-spirocyclization of N-arylpropiolamides: Access to 3-acylmethyl azaspiro[4,5]trienones

查看原文本刊更多论文

Visible-light-mediated oxidant-free tandem acylmethylation/ipso-spirocyclization of N-arylpropiolamides: Access to 3-acylmethyl azaspiro[4,5]trienones

A novel visible-light-mediated acylmethylation/ipso-spirocyclization of N-(p-methoxyaryl)propiolamides with α‑bromo ketones has been developed, enabling the efficient synthesis of diverse 3-acylmethyl functionalized azaspiro[4,5]trienones with high selectivity. This method constructs two new C–C bonds via a sequence of radical C–Br bond cleavage, ipso-spiroanulation and dearomatization. The reaction is operationally simple and scalable and features a broad substrate scope with good functional group tolerance, providing easy access to 3-acylmethyl azaspiro[4,5]trienones.

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来源期刊

Molecular Catalysis Chemical Engineering-Process Chemistry and Technology

CiteScore

6.90

自引率

10.90%

发文量

700

审稿时长

40 days

期刊介绍： Molecular Catalysis publishes full papers that are original, rigorous, and scholarly contributions examining the molecular and atomic aspects of catalytic activation and reaction mechanisms. The fields covered are: Heterogeneous catalysis including immobilized molecular catalysts Homogeneous catalysis including organocatalysis, organometallic catalysis and biocatalysis Photo- and electrochemistry Theoretical aspects of catalysis analyzed by computational methods