Roles of funny HCN

To some extent, the main role of hyperpolarization-activated cyclic nucleotide-gated non-selective cation channels (HCN, I_h, or I_f), pace-making, is dogmatized as a functional expression of one or another alpha subunit of HCN channels does not make every region of the brain or heart a pacemaker one. Recent research hints at the role of HCN in arrhythmias and seizures that are often caused by voltage-dependent K and Na channels (Kv and Nav) and neurotransmitters, respectively. There are many parallels between the HCN and K channels. Similar to Kv channels, an altered HCN function also leads to long QT interval. Moreover, a mutation in HCN is believed to trigger correlated arrhythmias and, e.g., epilepsy, among many other brain pathologies. Unlike Kv channels, although no dedicated ancillary beta subunit has been discovered for HCN, the I_h properties are also influenced by other elements and factors. A new interaction has been discovered between HCN and the vesicle-associated membrane protein (VAMP). The prevailing interaction occurs via the subtype VAMP-associated protein B (VAPB). However, this interaction is not unique but universal, since there is also a link between Kv2.1 and VAMP2 (vesicular SNARE). The most remarkable similitude is the fact that a selective antagonist of HCN and medication ivabradine prevents the I_Kr via the cloned human ether-à-go-go-related gene (HERG) channels, also known as KvLQT and Kv11.1 alpha subunit.