非编码RNA在疾病治疗中调控干细胞程序性死亡的作用

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-coding RNA Research Pub Date : 2025-04-23 DOI:10.1016/j.ncrna.2025.04.005

Ziling Liao , Weidong Liu , Lei Wang , Wen Xie , Chaoyan Yao , Qianping Huang , Xingjun Jiang , Caiping Ren

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引用次数: 0

摘要

细胞程序性死亡（PCD）是机体发育过程中不可避免的重要现象。它不仅能维持细胞的稳态，还能防止细胞的异常增殖，从而保护正常的生长发育免受有害因素的影响。它是由一个高度复杂和复杂的调控网络控制的，其中非编码rna （ncrna）起着关键作用。ncrna是指不编码蛋白质的RNA分子，包含多种类型，包括长链非编码RNA （lncRNA）、微RNA （miRNA）和环状RNA （circRNA）。在此，我们研究了ncRNAs调节干细胞的特定信号机制，阐明了它们通过与特定分子的相互作用在调节PCD过程中的作用。我们进一步总结了上述调节作用对干细胞分化、增殖、周期调控以及多种疾病发生和治疗的影响。此外，鉴于ncrna和干细胞治疗应用的新趋势，我们探索它们联合应用于疾病治疗的潜力。

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The role of non-coding RNA regulates stem cell programmed death in disease therapy

Programmed cell death (PCD), an essential and inevitable phenomenon, is integral to organismal development. It not only maintains cellular homeostasis but also prevents aberrant cell proliferation, thereby protecting normal growth and development from detrimental factors. And it is governed by a highly complex and sophisticated regulatory network in which non-coding RNAs (ncRNAs) play pivotal roles. ncRNAs refer to RNA molecules that do not encode proteins and encompass various types, including long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). Herein, we investigate the specific signaling mechanisms by which ncRNAs regulate stem cells, elucidating their role in modulating PCD process through interactions with specific molecules. We further summarize the impact of above modulating role on stem cell differentiation, proliferation, cycle regulation and diverse disease development and therapy. Additionally, given the emerging trends in the therapeutic application of ncRNAs and stem cells, we explore the potential of their combined application for disease treatment.

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来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.