人牛分枝杆菌感染：马德里分枝杆菌研究组（GEMIMAD）开展的一项多中心回顾性研究

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2025-05-01 DOI:10.1016/j.eimc.2024.09.014

Loreto Sangorrin-Lapieza , Alba Ruedas-López , Jaime Esteban , Carlos Toro , Laura Barrado , María Jesús Ruiz-Serrano , Jorge Anel , Diego Domingo , Alhena Reyes , Paula López-Roa

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引用次数: 0

摘要

本研究旨在评估牛分枝杆菌人结核病例的趋势和临床特征，描述流行病学特征，并比较与肺外和肺结核相关的危险因素。方法对2010 - 2022年西班牙马德里7家临床微生物实验室培养确诊的牛支原体感染病例进行回顾性队列分析。从医院数据库中提取社会人口学和临床数据。结核（TB）病例分为肺外结核（EPTB）和肺结核（PTB），弥散性结核排除在统计分析之外。结果3670例合并结核分枝杆菌感染患者中，检出牛分枝杆菌66例，占1.8%。肺结核和EPTB分别占45.5%和39.4%，其中15.1%为播散性结核。PTB与男性和西班牙国籍显著相关，而EPTB在女性和农村生活方式人群中更为普遍。结论本研究显示牛分枝杆菌结核病例呈上升趋势。中年患者，包括大量移民人口，主要受影响。女性性别和农村生活方式与肺外疾病有关。

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Human Mycobacterium bovis infection: A multicentre retrospective study conducted by the Madrid Study Group for Mycobacteria (GEMIMAD)

Introduction

This study aimed to evaluate trends and clinical characteristics of Mycobacterium bovis human tuberculosis cases, describe the epidemiological features, and compare risk factors associated with extrapulmonary and pulmonary tuberculosis.

Methods

A retrospective cohort analysis was conducted on M. bovis infection cases confirmed by culture from seven clinical microbiology laboratories in Madrid, Spain, from 2010 to 2022. Sociodemographic and clinical data were extracted from the hospital database. Tuberculosis (TB) cases were classified as extrapulmonary (EPTB) and pulmonary tuberculosis (PTB), with disseminated TB cases excluded from statistical analysis.

Results

Among 3670 patients with Mycobacterium tuberculosis complex infection, M. bovis was identified in 66 patients, representing 1.8% of the total. PTB and EPTB were identified in 45.5% and 39.4% of cases, respectively, with 15.1% having disseminated TB. PTB was significantly associated with males and Spanish nationality, while EPTB was more prevalent among females and those with a rural lifestyle.

Conclusions

The study revealed an escalating trend in M. bovis tuberculosis cases. Middle-aged patients, including a substantial immigrant population, were predominantly affected. Female gender and a rural lifestyle were associated to extrapulmonary disease.

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.