肠液分泌对十二指肠酸碱调节的模拟研究

IF 3.7 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chinese Journal of Chemical Engineering Pub Date : 2025-05-01 DOI:10.1016/j.cjche.2024.12.014

Yulan Zhao , Yifan Qin , Xiao Dong Chen , Jie Xiao

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引用次数: 0

摘要

肠液的分泌方式（即胰胆分泌和肠壁分泌）如何调节肠道酸碱环境，至今尚未完全了解。了解其调控机制不仅对肠道健康具有重要意义，而且对仿生软弹性反应器（SERs）的优化设计具有重要意义。在这项工作中，模拟了酸性胃液和碱性肠液在具有运动壁的三维十二指肠内的混合和反应。该模型的一个独特之处在于将胰胆管和肠壁分泌液作为边界条件。该模型使我们能够定量探索分泌方式对pH调节的影响。结果表明，胰胆和肠壁分泌物的共存是维持十二指肠平均pH值在7.4左右的关键。它们的共存协同促进了酸碱消化液的混合和反应，为肠道内的脂肪酶提供了合适的催化环境。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Acid-base regulation in duodenum by intestinal fluid secretion: A simulation study

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Acid-base regulation in duodenum by intestinal fluid secretion: A simulation study

Up to now, how the secretion modes of intestinal fluid (i.e., pancreaticobiliary secretion and wall secretion) can regulate intestinal acid-base environment has not been fully understood. Understanding the regulation mechanism is not only of great significance for intestinal health but may also lead to optimized designs for bio-inspired soft elastic reactors (SERs). In this work, the mixing and reaction of acidic gastric juice and alkaline intestinal fluid in a 3D duodenum with moving walls were modelled. A unique feature of this model is the implementation of both pancreaticobiliary and wall secretion of intestinal fluid as boundary conditions. This model allowed us to quantitatively explore the influence of secretion modes on pH regulation. The results demonstrated that coexistence of both pancreaticobiliary and wall secretions is the key to maintain the average pH in the duodenum at about 7.4. Their coexistence synergistically promotes the mixing and reaction of acid-base digestion liquids and provides a suitable catalytic environment for lipase in the intestine.

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来源期刊

Chinese Journal of Chemical Engineering 工程技术-工程：化工

CiteScore

6.60

自引率

5.30%

发文量

4309

审稿时长

31 days

期刊介绍： The Chinese Journal of Chemical Engineering (Monthly, started in 1982) is the official journal of the Chemical Industry and Engineering Society of China and published by the Chemical Industry Press Co. Ltd. The aim of the journal is to develop the international exchange of scientific and technical information in the field of chemical engineering. It publishes original research papers that cover the major advancements and achievements in chemical engineering in China as well as some articles from overseas contributors. The topics of journal include chemical engineering, chemical technology, biochemical engineering, energy and environmental engineering and other relevant fields. Papers are published on the basis of their relevance to theoretical research, practical application or potential uses in the industry as Research Papers, Communications, Reviews and Perspectives. Prominent domestic and overseas chemical experts and scholars have been invited to form an International Advisory Board and the Editorial Committee. It enjoys recognition among Chinese academia and industry as a reliable source of information of what is going on in chemical engineering research, both domestic and abroad.