n -杂环碳催化[4 + 2]环化可烯化硫酯合成2-吡咯酮

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-04-23 DOI:10.1021/acs.joc.5c0042810.1021/acs.joc.5c00428

Jinfeng Zhang, Chen Zhu, Xu Cao, Hui Jin* and Lixin Zhang*,

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引用次数: 0

摘要

n -杂环羰基（NHC）催化的[4 + 2]环化使α-氯硫酯和β，γ-不饱和α-酮酯或查尔酮直接合成2-吡咯酮。该方法利用nhc活化的α-氯硫酯生成具有高官能团耐受性的2-吡啶酮生成关键中间体。并将2-吡咯酮转化为多取代苯和萘衍生物，显示了它们的合成价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

N-Heterocyclic Carbene-Catalyzed [4 + 2] Annulation of Enolizable Thioesters for the Synthesis of 2-Pyrones

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N-Heterocyclic Carbene-Catalyzed [4 + 2] Annulation of Enolizable Thioesters for the Synthesis of 2-Pyrones

An N-heterocyclic carbene (NHC)-catalyzed [4 + 2] annulation enables the direct synthesis of 2-pyrones from α-chlorothioesters and β,γ-unsaturated α-keto esters or chalcones. The method utilizes NHC-activated α-chlorothioesters to generate key intermediates for 2-pyrone formation with high functional group tolerance. Moreover, the 2-pyrones were transformed into polysubstituted benzene and naphthalene derivatives, showcasing their synthetic value.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.