{"title":"提高生物电子学时空分辨率的材料和器件策略","authors":"Jing Zhang, Zhe Cheng, Pengju Li, Bozhi Tian","doi":"10.1038/s41578-025-00798-y","DOIUrl":null,"url":null,"abstract":"<p>Spatiotemporal resolution is a cornerstone of bioelectronics, enabling precise observation and control of biological events at the molecular, cellular and tissue levels. In this Review, we analyse recent advancements in spatiotemporal resolution essential for applications such as neuroprosthetics, cardiac monitoring and biosensing, with a focus on devices utilizing electrical, electrochemical and optoelectronic signal transduction. We define the intrinsic and extrinsic parameters of spatial and temporal resolution and highlight high-performance materials and device architectures — including electrodes, transistors and optoelectronic interfaces — that drive these capabilities. Strategies such as device miniaturization, 3D fabrication and multifunctional integration are evaluated for their capacity to improve resolution, particularly within the complex microenvironments of biological tissues. However, challenges persist, including signal interference, device stability and the demand for reliable long-term operation. Overcoming these obstacles requires continuous innovation in materials science, device engineering and computational approaches. Enhanced spatiotemporal resolution holds promise for advancing diagnostic precision, therapeutic responsiveness and our understanding of dynamic biological systems across biomedical disciplines.</p>","PeriodicalId":19081,"journal":{"name":"Nature Reviews Materials","volume":"25 1","pages":""},"PeriodicalIF":79.8000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Materials and device strategies to enhance spatiotemporal resolution in bioelectronics\",\"authors\":\"Jing Zhang, Zhe Cheng, Pengju Li, Bozhi Tian\",\"doi\":\"10.1038/s41578-025-00798-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Spatiotemporal resolution is a cornerstone of bioelectronics, enabling precise observation and control of biological events at the molecular, cellular and tissue levels. In this Review, we analyse recent advancements in spatiotemporal resolution essential for applications such as neuroprosthetics, cardiac monitoring and biosensing, with a focus on devices utilizing electrical, electrochemical and optoelectronic signal transduction. We define the intrinsic and extrinsic parameters of spatial and temporal resolution and highlight high-performance materials and device architectures — including electrodes, transistors and optoelectronic interfaces — that drive these capabilities. Strategies such as device miniaturization, 3D fabrication and multifunctional integration are evaluated for their capacity to improve resolution, particularly within the complex microenvironments of biological tissues. However, challenges persist, including signal interference, device stability and the demand for reliable long-term operation. Overcoming these obstacles requires continuous innovation in materials science, device engineering and computational approaches. Enhanced spatiotemporal resolution holds promise for advancing diagnostic precision, therapeutic responsiveness and our understanding of dynamic biological systems across biomedical disciplines.</p>\",\"PeriodicalId\":19081,\"journal\":{\"name\":\"Nature Reviews Materials\",\"volume\":\"25 1\",\"pages\":\"\"},\"PeriodicalIF\":79.8000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1038/s41578-025-00798-y\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1038/s41578-025-00798-y","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Materials and device strategies to enhance spatiotemporal resolution in bioelectronics
Spatiotemporal resolution is a cornerstone of bioelectronics, enabling precise observation and control of biological events at the molecular, cellular and tissue levels. In this Review, we analyse recent advancements in spatiotemporal resolution essential for applications such as neuroprosthetics, cardiac monitoring and biosensing, with a focus on devices utilizing electrical, electrochemical and optoelectronic signal transduction. We define the intrinsic and extrinsic parameters of spatial and temporal resolution and highlight high-performance materials and device architectures — including electrodes, transistors and optoelectronic interfaces — that drive these capabilities. Strategies such as device miniaturization, 3D fabrication and multifunctional integration are evaluated for their capacity to improve resolution, particularly within the complex microenvironments of biological tissues. However, challenges persist, including signal interference, device stability and the demand for reliable long-term operation. Overcoming these obstacles requires continuous innovation in materials science, device engineering and computational approaches. Enhanced spatiotemporal resolution holds promise for advancing diagnostic precision, therapeutic responsiveness and our understanding of dynamic biological systems across biomedical disciplines.
期刊介绍:
Nature Reviews Materials is an online-only journal that is published weekly. It covers a wide range of scientific disciplines within materials science. The journal includes Reviews, Perspectives, and Comments.
Nature Reviews Materials focuses on various aspects of materials science, including the making, measuring, modelling, and manufacturing of materials. It examines the entire process of materials science, from laboratory discovery to the development of functional devices.