Fuxing Xu, Zongli Xiong, Wenling Qin, Weijun Yao, Zhen Wang
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Asymmetric Synthesis of Quinolinone-based Polycyclic Indoles through [1,3]-Rearrangement/cyclization Reaction
We have developed an enantioselective [1,3]-rearrangement/ cyclization reaction that provides efficient access to quinolinone-based polycyclic indole derivatives. This catalytic system exhibits broad substrate scope, enabling the stereocontrolled synthesis of two valuable scaffolds: 3,4-dihydroquinolin-2-ones and cyclopenta[b]indoles with excellent stereoselectivity (>40 examples, 83-99% ee, >19:1 dr). Notably, the obtained products demonstrate promising anticancer activity.
期刊介绍:
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.