维持溃疡性结肠炎的缓解

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-05-01 DOI:10.1038/s41575-025-01073-9

Eleni Kotsiliti

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引用次数: 0

摘要

发表在《柳叶刀胃肠病学》杂志上的一项新的临床研究；肝病学评估了腹腔镜阑尾切除术在维持溃疡性结肠炎缓解方面的有效性。从2012年到2022年，1386名溃疡性结肠炎缓解患者在荷兰、爱尔兰和英国的22个中心进行了一项实用、开放标签、随机对照优势试验（ACCURE）。其中，197例患者被随机分配（1:1）接受阑尾切除术加持续维持药物治疗或单独继续维持治疗（对照组）。这些患者被纳入意向治疗分析，主要结局是1年内疾病复发的患者比例。

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Maintaining remission in ulcerative colitis

A new clinical study published in The Lancet Gastroenterology & Hepatology assessed the effectiveness of laparoscopic appendicectomy in maintaining remission in ulcerative colitis.

From 2012 to 2022, 1,386 patients with ulcerative colitis in remission were initially screened in a pragmatic, open-label, randomized controlled superiority trial (ACCURE) in 22 centres across the Netherlands, Ireland and the UK. Of those, 197 patients were randomly assigned (1:1) to undergo appendicectomy plus continued maintenance medical therapy or to continue maintenance therapy alone (control group). The patients were included in the intention-to-treat analyses, and the primary outcome was the proportion of patients with a disease relapse within 1 year.

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.