Julie D. Henry , Sarah P. Coundouris , Izelle Labuschagne , Kirra Liu , Simon J. Haines , Sarah A. Grainger , Juan F. Domínguez , Alex Puckett , Peter G. Rendell , Jessica Taubert
{"title":"与年龄相关的神经完整性差异与前瞻记忆的年龄效应无关","authors":"Julie D. Henry , Sarah P. Coundouris , Izelle Labuschagne , Kirra Liu , Simon J. Haines , Sarah A. Grainger , Juan F. Domínguez , Alex Puckett , Peter G. Rendell , Jessica Taubert","doi":"10.1016/j.bandc.2025.106301","DOIUrl":null,"url":null,"abstract":"<div><div>Prospective memory refers to memory for future intentions. In general, prospective memory appears to decline with age when tested in laboratory settings but is preserved or enhanced when tasks need to be completed in daily life. No study to date has tested whether age-related differences in specific brain structures and networks mediate prospective memory age effects in both settings. Here, measures of regional brain volume (anterior prefrontal cortex, frontoparietal networks, and temporal lobes), white matter integrity (prefrontal white matter hypointensities) and prospective memory were obtained from 41 younger and 41 older adults. The results showed that, as expected, older age was associated with smaller regional brain volumes, as well as poorer prefrontal white matter integrity. In addition, age was negatively associated with prospective memory function in the laboratory-based assessment, but positively associated with performance on the task completed in daily life. However, none of these behavioural effects were mediated by age-related differences in neural integrity. These data show that, in contrast to literature focused on neurodegenerative disease in which neural losses have been shown to be predictive of PM impairment, age-related differences in brain integrity may not be the best indicator of <em>normal</em> variation in prospective memory function.</div></div>","PeriodicalId":55331,"journal":{"name":"Brain and Cognition","volume":"187 ","pages":"Article 106301"},"PeriodicalIF":2.2000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-related differences in neural integrity are unrelated to prospective memory age effects\",\"authors\":\"Julie D. Henry , Sarah P. Coundouris , Izelle Labuschagne , Kirra Liu , Simon J. Haines , Sarah A. Grainger , Juan F. Domínguez , Alex Puckett , Peter G. Rendell , Jessica Taubert\",\"doi\":\"10.1016/j.bandc.2025.106301\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Prospective memory refers to memory for future intentions. In general, prospective memory appears to decline with age when tested in laboratory settings but is preserved or enhanced when tasks need to be completed in daily life. No study to date has tested whether age-related differences in specific brain structures and networks mediate prospective memory age effects in both settings. Here, measures of regional brain volume (anterior prefrontal cortex, frontoparietal networks, and temporal lobes), white matter integrity (prefrontal white matter hypointensities) and prospective memory were obtained from 41 younger and 41 older adults. The results showed that, as expected, older age was associated with smaller regional brain volumes, as well as poorer prefrontal white matter integrity. In addition, age was negatively associated with prospective memory function in the laboratory-based assessment, but positively associated with performance on the task completed in daily life. However, none of these behavioural effects were mediated by age-related differences in neural integrity. These data show that, in contrast to literature focused on neurodegenerative disease in which neural losses have been shown to be predictive of PM impairment, age-related differences in brain integrity may not be the best indicator of <em>normal</em> variation in prospective memory function.</div></div>\",\"PeriodicalId\":55331,\"journal\":{\"name\":\"Brain and Cognition\",\"volume\":\"187 \",\"pages\":\"Article 106301\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain and Cognition\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0278262625000417\",\"RegionNum\":3,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain and Cognition","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0278262625000417","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Age-related differences in neural integrity are unrelated to prospective memory age effects
Prospective memory refers to memory for future intentions. In general, prospective memory appears to decline with age when tested in laboratory settings but is preserved or enhanced when tasks need to be completed in daily life. No study to date has tested whether age-related differences in specific brain structures and networks mediate prospective memory age effects in both settings. Here, measures of regional brain volume (anterior prefrontal cortex, frontoparietal networks, and temporal lobes), white matter integrity (prefrontal white matter hypointensities) and prospective memory were obtained from 41 younger and 41 older adults. The results showed that, as expected, older age was associated with smaller regional brain volumes, as well as poorer prefrontal white matter integrity. In addition, age was negatively associated with prospective memory function in the laboratory-based assessment, but positively associated with performance on the task completed in daily life. However, none of these behavioural effects were mediated by age-related differences in neural integrity. These data show that, in contrast to literature focused on neurodegenerative disease in which neural losses have been shown to be predictive of PM impairment, age-related differences in brain integrity may not be the best indicator of normal variation in prospective memory function.
期刊介绍:
Brain and Cognition is a forum for the integration of the neurosciences and cognitive sciences. B&C publishes peer-reviewed research articles, theoretical papers, case histories that address important theoretical issues, and historical articles into the interaction between cognitive function and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in cognition. Coverage includes, but is not limited to memory, learning, emotion, perception, movement, music or praxis in relationship to brain structure or function. Published articles will typically address issues relating some aspect of cognitive function to its neurological substrates with clear theoretical import, formulating new hypotheses or refuting previously established hypotheses. Clinical papers are welcome if they raise issues of theoretical importance or concern and shed light on the interaction between brain function and cognitive function. We welcome review articles that clearly contribute a new perspective or integration, beyond summarizing the literature in the field; authors of review articles should make explicit where the contribution lies. We also welcome proposals for special issues on aspects of the relation between cognition and the structure and function of the nervous system. Such proposals can be made directly to the Editor-in-Chief from individuals interested in being guest editors for such collections.