Core-shell bimetallic alloyed Pd@Pt nanocubes for synergistic photothermal/chemodynamic infectious wound therapy

Infections resulting from bacteria resistant to antibiotics represent a significant risk to human health. Therefore, exploring novel and effective antibacterial treatment strategies as substitutes for traditional antibiotics is essential. Here, we developed heterogeneous bimetallic Pd@Pt Cubes with a core-shell structure for near-infrared light-enhanced bacterial infection treatment. Heterogeneous core-shell bimetallic Pd@Pt nanocubes demonstrated remarkable photothermal properties along with peroxidase-mimic activity, promoting the combined interaction between photothermal antibacterial therapy (PTT) and chemodynamic therapy (CDT). As demonstrated in vitro antibacterial tests, Pd@Pt Cubes can effectively eliminate both E. coli and S. aureus, and enhance drug penetration in biofilm by disrupting the biofilm. Furthermore, in vivo antibacterial tests indicated that Pd@Pt Cubes can significantly enhance the repair of tissues in bacterial infection sites. Overall, this study constructed an efficient and multifunctional antibacterial nanoplatform through a rational combination and design, and achieved PTT/CDT bimodal bacterial infection treatment through multiple enhancement strategies.