口腔微生物群与百岁老人的认知状态有关：一项临床和生物学研究

IF 3.9 2区医学 Q2 GERIATRICS & GERONTOLOGY

Maturitas Pub Date : 2025-04-29 DOI:10.1016/j.maturitas.2025.108593

Giuseppina Campisciano , Katia Rupel , Federica D'Amico , Mauro Tettamanti , Filomena Vella , Carolina Cason , Manola Comar , Silvia Turroni , Gabriella Marcon

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引用次数: 0

摘要

目的越来越多的证据支持口腔微生物群在影响认知功能方面的潜在作用。百岁老人是研究炎症长期影响的理想人群，他们处于生命的尽头。研究设计由神经学家、神经心理学家和牙医对23名百岁老人进行了检查，以评估认知状况和口腔健康状况。他们还进行了口腔微生物群和炎性体的分析。结果我们发现痴呆患者口腔微生物群α多样性减少，典型的口腔共生菌总体减少，包括异丙普氏菌、普氏菌、细孔菌、梭菌和钩毛菌。与有齿受试者相比，后两者在无牙受试者中的代表性也不足。此外，痴呆患者的促炎细胞因子和趋化因子水平往往更高。结论口腔微生物群、认知状态和炎症之间存在相关性，值得进一步探索，以对抗认知能力下降，促进健康衰老。

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Oral microbiota profile is related to cognitive status in centenarians: a clinical and biological study

Objectives

A growing body of evidence supports the potential role of the oral microbiota in influencing cognitive function. Centenarians, at the extreme end of the lifespan, are the ideal cohort to study the long-term effects of inflammaging.

Study design

Twenty-three centenarians were examined by a neurologist, neuropsychologist and dentist to assess cognitive status and oral health. They were also profiled for oral microbiota and inflammasome.

Results

We found less alpha diversity in the oral microbiota of participants with dementia and an overall depletion of typical oral commensals, including Alloprevotella, Prevotella, Veillonella, Fusobacterium and Leptotrichia. The latter two were also underrepresented in edentulous compared with dentate subjects. Moreover, levels of pro-inflammatory cytokines and chemokines tended to be higher in participants with dementia.

Conclusions

Our data support a relationship between oral microbiota, cognitive status and inflammation, which deserves further exploration to counteract cognitive decline while promoting healthy aging.

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来源期刊

Maturitas 医学-妇产科学

CiteScore

9.10

自引率

2.00%

发文量

142

审稿时长

40 days

期刊介绍： Maturitas is an international multidisciplinary peer reviewed scientific journal of midlife health and beyond publishing original research, reviews, consensus statements and guidelines, and mini-reviews. The journal provides a forum for all aspects of postreproductive health in both genders ranging from basic science to health and social care. Topic areas include:• Aging• Alternative and Complementary medicines• Arthritis and Bone Health• Cancer• Cardiovascular Health• Cognitive and Physical Functioning• Epidemiology, health and social care• Gynecology/ Reproductive Endocrinology• Nutrition/ Obesity Diabetes/ Metabolic Syndrome• Menopause, Ovarian Aging• Mental Health• Pharmacology• Sexuality• Quality of Life