近端位置作为腺瘤切除后异时性结直肠癌的预测因子。

The American Journal of Gastroenterology Pub Date : 2025-04-29 DOI:10.14309/ajg.0000000000003505

Sandra Baile-Maxía,Carolina Mangas-Sanjuán,Uri Ladabaum,Carmen Sánchez Ardila,Pedro Zapater,Rodrigo Jover

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引用次数: 0

摘要

目的比较异时性结直肠癌（CRC）和晚期腺瘤（AA）在近端和远端腺瘤患者中的风险。方法：我们检索Pubmed、EMBASE和Cochrane进行队列研究和临床试验。近端腺瘤位于降结肠近端。采用随机效应模型计算CRC和AA的合并发病率比（IRR）。结果与只有远端腺瘤的患者相比，任何近端腺瘤患者发生异时性CRC （1.70, 95%CI 1.17-2.45）、近端CRC （3.65,95%CI 1.57-8.46）和AA （1.82,95%CI 1.41-2.34）的风险更高。结论基线腺瘤近端位置与未来CRC和AA的检测相关。

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PROXIMAL LOCATION AS A PREDICTOR OF METACHRONOUS COLORECTAL CANCER AFTER EXCISION OF ADENOMAS.

OBJECTIVES To compare metachronous colorectal cancer (CRC) and advanced adenoma (AA) risk in patients with proximal vs. distal adenomas. METHODS We searched Pubmed, EMBASE, and Cochrane for cohort studies and clinical trials. Proximal adenomas were those located proximal to the descending colon. Pooled incidence rate ratios (IRR) for CRC and AA were calculated using a random-effects model. RESULTS Compared with patients with only distal adenomas, patients with any proximal adenoma had a higher risk of metachronous CRC (1.70, 95%CI 1.17-2.45), proximal CRC (3.65,95%CI 1.57-8.46), and AA (1.82,95%CI 1.41-2.34). CONCLUSIONS Baseline adenoma proximal location is associated with future detection of CRC and AA.

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The American Journal of Gastroenterology

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