Jessica Samuelsson, Anna Stubbendorff, Anna Marseglia, Olof Lindberg, Caroline Dartora, Sara Shams, Nira Cedres, Silke Kern, Johan Skoog, Lina Rydén, Eric Westman, Ingmar Skoog
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Neuroimaging measures included cortical thickness, hippocampal volume, small vessel disease, and deep learning-derived brain age. Cognitive performance was assessed with a global cognitive composite score.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>In multi-adjusted models, higher adherence to the EAT-Lancet diet was associated with higher total mean cortical thickness, and thicker cortex in Alzheimer's disease-signature regions, while a higher adherence to the MeDi was associated with better cognitive performance.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>The results indicate the beneficial effects of both the EAT-Lancet and the MeDi on brain health.</p>\n </section>\n \n <section>\n \n <h3> HIGHLIGHTS</h3>\n \n <div>\n <ul>\n \n <li>There were no indications of detrimental effects of adhering to the EAT-Lancet diet.</li>\n \n <li>Adhering to the EAT-Lancet planetary health diet was associated with thicker cortex.</li>\n \n <li>Results confirm links between the Mediterranean diet and better cognitive function.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70191","citationCount":"0","resultStr":"{\"title\":\"A comparative study of the EAT-Lancet diet and the Mediterranean diet in relation to neuroimaging biomarkers and cognitive performance\",\"authors\":\"Jessica Samuelsson, Anna Stubbendorff, Anna Marseglia, Olof Lindberg, Caroline Dartora, Sara Shams, Nira Cedres, Silke Kern, Johan Skoog, Lina Rydén, Eric Westman, Ingmar Skoog\",\"doi\":\"10.1002/alz.70191\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> BACKGROUND</h3>\\n \\n <p>The impact of the sustainable EAT-Lancet planetary health diet on brain and cognitive health remains unclear. 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A comparative study of the EAT-Lancet diet and the Mediterranean diet in relation to neuroimaging biomarkers and cognitive performance
BACKGROUND
The impact of the sustainable EAT-Lancet planetary health diet on brain and cognitive health remains unclear. This study compared the impact of the EAT-Lancet diet with the well-established cognitive-beneficial Mediterranean diet (MeDi) in relation to neuroimaging biomarkers and cognitive performance among older adults.
METHODS
The study included 615 dementia-free 70-year-olds from the Swedish population-based Gothenburg H70 Birth Cohort study. Dietary adherence was measured with EAT-Lancet diet and MeDi scores. Neuroimaging measures included cortical thickness, hippocampal volume, small vessel disease, and deep learning-derived brain age. Cognitive performance was assessed with a global cognitive composite score.
RESULTS
In multi-adjusted models, higher adherence to the EAT-Lancet diet was associated with higher total mean cortical thickness, and thicker cortex in Alzheimer's disease-signature regions, while a higher adherence to the MeDi was associated with better cognitive performance.
DISCUSSION
The results indicate the beneficial effects of both the EAT-Lancet and the MeDi on brain health.
HIGHLIGHTS
There were no indications of detrimental effects of adhering to the EAT-Lancet diet.
Adhering to the EAT-Lancet planetary health diet was associated with thicker cortex.
Results confirm links between the Mediterranean diet and better cognitive function.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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