生产用于寻骨的放射性药物的治疗性放射性核素，以满足临床需求和学术研究

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-03-04 DOI:10.1007/s10967-025-10025-1

Ashutosh Dash, Tapas Das

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引用次数: 0

摘要

本文对治疗性放射性核素（32P、89Sr、117mSn、153Sm、166Ho、186Re、188Re、177Lu和223Ra）的生产进行了全面而深入的综述，这些放射性核素对骨靶向性放射性药物的开发至关重要。这些放射性核素不仅在放射性药物开发的早期阶段至关重要，而且在确保其持续成功、可靠和进步方面也至关重要。该手稿强调了该领域最近的创新和趋势，解决了重大挑战和新兴机遇。它还审查了监管环境，并强调自动化在提高生产过程中的日益重要的作用。

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Production of therapeutic radionuclides for bone-seeking radiopharmaceuticals to meet clinical exigency and academic research

This review offers a comprehensive and insightful overview of the production of therapeutic radionuclides (³²P, ⁸⁹Sr, ^117mSn, ¹⁵³Sm, ¹⁶⁶Ho, ¹⁸⁶Re, ¹⁸⁸Re, ¹⁷⁷Lu and ²²³Ra), which are essential for developing bone-targeting radiopharmaceuticals. These radionuclides are critical not only in the early stages of radiopharmaceutical development but also in ensuring their continued success, reliability, and progress. The manuscript highlights recent innovations and trends in the field, addressing significant challenges and emerging opportunities. It also examines the regulatory environment and emphasizes the growing role of automation in enhancing the production process.

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.