含正磷酸钙颗粒复合材料在不同浸泡介质中的降解研究

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-04-16 DOI:10.1016/j.jmbbm.2025.107009

Handially dos Santos Vilela, Tarsila Vaz Marcolino Alves, Amanda Lopes Campos, Rafael Bergamo Trinca, Roberto Ruggiero Braga

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引用次数: 0

摘要

本研究的目的是评估在不同介质中长时间浸泡对含有二水磷酸二钙颗粒（DCPD, CaHPO4.2H2O）的复合材料力学性能的影响。制备了三种树脂相相同的配方（BisGMA/TEGMA，摩尔比为1:1）。总无机物含量为50 vol%，由钡玻璃（BG）或BG和DCPD的混合物（15:35或35:15 vol%）组成。利用FTIR光谱（n = 3）测定了复合材料的转化率（DC）。在去离子水（DW）、柠檬酸（CA, pH 5）或75%乙醇溶液（EtOH）中分别作用24 h和6个月后，采用“活塞-三球”法（n = 13）测定了双轴抗弯强度（BFS）和抗弯模量（FM）。在弯曲试件的碎片中测定Knoop显微硬度（KHN, n = 6）。数据分析采用方差分析/Tukey检验（alpha: 5%）。35% DCPD的DC在统计学上更高(p <；0.001)。总体而言，在所有三种介质和两种储存时间中，机械性能与DCPD分数呈负相关。在大多数测试条件下，15% DCPD复合材料的BFS与对照组在统计学上相似，并且在所有培养基中24小时后的FM相似。然而，在24小时和6个月后，CA对含有DCPD的复合材料的KHN都有严重的负面影响，而与DW相比，EtOH对对照的KHN的降低幅度最大。基于这些结果，我们得出结论，含有DCPD的复合材料比对照具有更高的表面降解，这可能限制了它们作为块状修复材料的使用。

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Degradation of experimental composites containing calcium orthophosphate particles in different immersion media

The aim of the present study was to evaluate the effect of prolonged immersion in different media on the mechanical properties of composites containing dicalcium phosphate dihydrate particles (DCPD, CaHPO₄.2H₂O). Three formulations with the same resin phase (BisGMA/TEGMA, 1:1 in moles) were prepared. The total inorganic content was 50 vol%, consisting of barium glass (BG) or a mixture of BG and DCPD (15:35 or 35:15 vol%). The degree of conversion (DC) of the composites was determined using FTIR spectroscopy (n = 3). Biaxial flexural strength (BFS) and flexural modulus (FM) were determined using the “piston-on-three-spheres” method (n = 13) after 24 h and 6 months in deionized water (DW), citric acid (CA, pH 5) or 75 % ethanol solution (EtOH). Knoop microhardness (KHN, n = 6) was determined in fragments of the flexural test specimens. Data were analysed using ANOVA/Tukey's test (alpha: 5 %). DC was statistically higher for the 35 % DCPD composite (p < 0.001). Overall, mechanical properties were inversely related to DCPD fraction in all three media and both storage times. The 15 % DCPD composite had BFS statistically similar to the control in most of the tested conditions, and similar FM after 24h in all media. However, CA had a severe negative effect on the KHN of composites containing DCPD both after 24h and 6 months, while EtOH caused the highest reduction in KHN for the control, in comparison to DW. Based on these results, it is concluded that composites containing DCPD presented higher surface degradation than the control, which may limit their use as bulk restoratives.

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.