Facile fabrication of a ternary drug-carrying polymeric composite coatings with enhanced interface compatibility and mechanical properties by suspension flame spray

In this study, the interface-modified ternary blends based on polylactic acid (PLLA)-polycaprolactone (PCL)-polycarbonate diols (PCDL) were prepared via suspension flame spray. Morphological analysis showed that the interface modification of PCDL significantly improves the compatibility of PLLA and PCL. Mechanical analysis revealed that the addition of PCDL resulted in great enhancement of the toughness of the PLLA/PCL composite coatings with a dramatic 326 % increase of the fracture strain for 10PLLA/90PCL/10PCDL compared with 10PLLA/90PCL. Further physicochemical and antibacterial test revealed no significant difference among PLLA/PCL and PLLA/PCL/CAM composite coatings with and without PCDL. Time-course release analysis showed that the release mechanism of the composite coating generally remains the same when the PCDL added is lower than the main components in PLLA/PCL, and even changed from the original abnormal diffusion to Fick diffusion. Overall, the ternary blending approach of PLLA-PCL-PCDL using suspension flame spray is a promising technique with great potential drug-delivery applications with different mechanical requirements.