胆固醇吸附材料的设计与研究进展

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Process Biochemistry Pub Date : 2025-04-24 DOI:10.1016/j.procbio.2025.04.016

Zhihe Yang , Wen Huang , Zhangrong Tang , Tianyi Li , Jiongcheng Lu , Lili Cai , Yong-Guang Jia

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引用次数: 0

摘要

胆固醇在人体代谢中起着至关重要的作用，因此胆固醇稳态和代谢外排对临床治疗高胆固醇疾病具有重要意义。因此，人们开发了各种吸附和去除方法来降低人体内的胆固醇含量，但药物的副作用和禁忌症增加了临床治疗的不便程度。因此，多种胆固醇吸附材料，如分子印迹材料和主客体聚合物材料，在高胆固醇相关疾病的治疗中显示出巨大的潜力。β-环糊精是一种能够识别胆固醇的天然大环分子，β-环糊精与胆固醇之间的主客体复合物用于特异性吸附和去除胆固醇。本文综述了近年来胆固醇吸附材料的设计和研究进展，特别是β-环糊精-胆固醇主客识别材料的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent progress in the design and research of cholesterol adsorption materials

Cholesterol plays a vital role in human metabolism, so cholesterol homeostasis and metabolic efflux are highly important for the clinical treatment of high-cholesterol diseases. Therefore, various adsorption and removal methods have been developed to reduce the cholesterol content in the human body, but the side effects and contraindications of drugs have increased the degree of inconvenience of clinical treatment. Thus, a variety of cholesterol adsorption materials, such as molecular imprinting materials and hostguest polymeric materials, have shown great potential in the treatment of high cholesterol-related diseases. β-cyclodextrin is a natural macrocyclic molecule that can recognize cholesterol, and the host-guest complex between β-cyclodextrin and cholesterol is used for specific adsorption and removal of cholesterol. In this review, we summarize recent progress in the design and research of cholesterol adsorption materials, especially those focused on β-cyclodextrin-cholesterol host-guest recognition-based materials.

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来源期刊

Process Biochemistry 生物-工程：化工

CiteScore

8.30

自引率

4.50%

发文量

374

审稿时长

53 days

期刊介绍： Process Biochemistry is an application-orientated research journal devoted to reporting advances with originality and novelty, in the science and technology of the processes involving bioactive molecules and living organisms. These processes concern the production of useful metabolites or materials, or the removal of toxic compounds using tools and methods of current biology and engineering. Its main areas of interest include novel bioprocesses and enabling technologies (such as nanobiotechnology, tissue engineering, directed evolution, metabolic engineering, systems biology, and synthetic biology) applicable in food (nutraceutical), healthcare (medical, pharmaceutical, cosmetic), energy (biofuels), environmental, and biorefinery industries and their underlying biological and engineering principles.