{"title":"基于苯并噻吩的两亲性光敏剂：探索聚集诱导的活性氧生成增强","authors":"Yujie Feng, Yahui Liu, Andong Zhang*, Changdong Zhang* and Zhishan Bo*, ","doi":"10.1021/acsami.5c0497410.1021/acsami.5c04974","DOIUrl":null,"url":null,"abstract":"<p >The application of photosensitizers has long been hindered by complex synthesis routes and poor water solubility. In this study, we report novel benzothioxene-based photosensitizers with significant improvements in both solubility and photodynamic efficiency. Among them, the amphiphilic molecule QA-BTXI stands out, offering exceptional water solubility and pronounced aggregation-induced enhancement of reactive oxygen species generation. At a low concentration of 25 μM, QA-BTXI exhibits potent antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Additionally, QA-BTXI is synthesized in a cost-effective manner with 82% yield and a straightforward purification process. These findings present a promising approach to developing next-generation photosensitizers with broad potential for large-scale production and practical applications.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"17 17","pages":"25182–25192 25182–25192"},"PeriodicalIF":8.2000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Amphiphilic Photosensitizer Based on Benzothioxanthene: Exploring Aggregation-Induced Enhancement of Reactive Oxygen Species Generation\",\"authors\":\"Yujie Feng, Yahui Liu, Andong Zhang*, Changdong Zhang* and Zhishan Bo*, \",\"doi\":\"10.1021/acsami.5c0497410.1021/acsami.5c04974\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The application of photosensitizers has long been hindered by complex synthesis routes and poor water solubility. In this study, we report novel benzothioxene-based photosensitizers with significant improvements in both solubility and photodynamic efficiency. Among them, the amphiphilic molecule QA-BTXI stands out, offering exceptional water solubility and pronounced aggregation-induced enhancement of reactive oxygen species generation. At a low concentration of 25 μM, QA-BTXI exhibits potent antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Additionally, QA-BTXI is synthesized in a cost-effective manner with 82% yield and a straightforward purification process. These findings present a promising approach to developing next-generation photosensitizers with broad potential for large-scale production and practical applications.</p>\",\"PeriodicalId\":5,\"journal\":{\"name\":\"ACS Applied Materials & Interfaces\",\"volume\":\"17 17\",\"pages\":\"25182–25192 25182–25192\"},\"PeriodicalIF\":8.2000,\"publicationDate\":\"2025-04-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Materials & Interfaces\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsami.5c04974\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsami.5c04974","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Amphiphilic Photosensitizer Based on Benzothioxanthene: Exploring Aggregation-Induced Enhancement of Reactive Oxygen Species Generation
The application of photosensitizers has long been hindered by complex synthesis routes and poor water solubility. In this study, we report novel benzothioxene-based photosensitizers with significant improvements in both solubility and photodynamic efficiency. Among them, the amphiphilic molecule QA-BTXI stands out, offering exceptional water solubility and pronounced aggregation-induced enhancement of reactive oxygen species generation. At a low concentration of 25 μM, QA-BTXI exhibits potent antibacterial activity against Escherichia coli and Staphylococcus aureus. Additionally, QA-BTXI is synthesized in a cost-effective manner with 82% yield and a straightforward purification process. These findings present a promising approach to developing next-generation photosensitizers with broad potential for large-scale production and practical applications.
期刊介绍：
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
