通过分子成像激活的化学动力学诊断

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-04-28 DOI:10.1021/acs.nanolett.5c01444

Meng Li, Yafei Zhang, Yumeng Wu, Shan Lei, Hui Fang, Peng Huang, Jing Lin

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引用次数: 0

摘要

化学动力疗法（CDT）是一种很有前途的肿瘤治疗策略，但实时体内监测仍然具有挑战性。在这里，我们报告了一种可激活的分子成像激活伴随诊断传感器（CFG），用于实时监测CDT。CFG利用葡萄糖氧化酶（GOx）产生过氧化氢来启动Fenton反应，同时产生H+来激活荧光（FL）和光声（PA）信号。发现FL/PA强度与Fenton反应效率呈正相关（·OH-FL的Pearson’s r = 0.98，·OH-PA的Pearson’s r = 0.90），从而可以对GOx催化引发的CDT进行动态可视化。此外，CFG的H+活化光热效应使FL/PA成像能够确定最佳照射时间，以最大化轻度高温增强CDT。因此，通过追踪H+动力学，收集针对性反馈，监测治疗反应和指导治疗，揭示酶催化、亚热疗和CDT之间的级联效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Activatable Chemodynamic Theranostics through Molecular Imaging-Energized Companion Diagnostics

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Activatable Chemodynamic Theranostics through Molecular Imaging-Energized Companion Diagnostics

Chemodynamic therapy (CDT) is a promising tumor treatment strategy, yet real-time in vivo monitoring remains challenging. Here, we report an activatable molecular imaging-energized companion diagnostics sensor (CFG) for real-time monitoring of CDT. CFG leverages glucose oxidase (GOx) to generate hydrogen peroxide to prime the Fenton reaction, while simultaneously producing H⁺ to activate the fluorescence (FL) and photoacoustic (PA) signals. A positive correlation between the FL/PA intensities and the Fenton reaction efficiency is found (Pearson’s r = 0.98 for ·OH-FL, 0.90 for ·OH-PA), enabling dynamic visualization of the GOx catalysis-primed CDT. Also, H⁺-activated photothermal effect of CFG enables FL/PA imaging to pinpoint the optimal irradiation time for maximizing mild hyperthermia-enhanced CDT. Therefore, by tracing the H⁺ dynamics, tailored feedback is collected for therapeutic response monitoring and treatment guidance, and the cascade effect between enzyme catalysis, mild hyperthermia, and CDT is revealed.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.