分泌乙酰胆碱的B细胞抑制巨噬细胞对流感病毒的反应

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-04-29 DOI:10.1038/s41590-025-02148-0

引用次数: 0

摘要

在我们的研究中，我们确定了一种调节途径，通过该途径，B细胞释放神经递质乙酰胆碱抑制流感病毒感染早期肺间质巨噬细胞产生TNF。通过这种方式，B细胞减少了早期肺部炎症并支持最终的组织再生，尽管减少了病毒复制的早期控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Acetylcholine-secreting B cells constrain macrophage responses to influenza virus

查看原文本刊更多论文

Acetylcholine-secreting B cells constrain macrophage responses to influenza virus

In our study, we identify a regulatory pathway by which release of the neurotransmitter acetylcholine by B cells suppresses TNF production by lung interstitial macrophages early in influenza virus infection. In this way, B cells reduce early lung inflammation and support eventual tissue regeneration, despite reducing early control of viral replication.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.