研究血浆脂质谱与帕金森病风险的关系

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-04-28 DOI:10.1038/s41531-025-00955-8

Houwen Zhang, Fangzheng Cao, Jialin Yu, Yu Liang, You Wu

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引用次数: 0

摘要

帕金森病（PD）与脂质代谢紊乱有关，但脂质在其发病机制中的具体作用尚不清楚。这项孟德尔随机化（MR）研究利用GWAS数据和IVW方法调查血浆脂质和PD风险。三酰甘油（TAGs）、二酰甘油（dag）、磷脂酰胆碱（PCs）和磷脂酰乙醇胺（PEs）水平改变的遗传易感性与PD风险增加有关，而鞘磷脂（SM）和溶磷脂酰胆碱（LPCs）的遗传易感性与PD风险降低有关。需要进一步的研究来确定这些关系背后的生物学机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Investigating plasma lipid profiles in association with Parkinson’s disease risk

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Investigating plasma lipid profiles in association with Parkinson’s disease risk

Parkinson’s Disease (PD) is associated with lipid metabolic disturbances, but the specific roles of lipids in its pathogenesis are unclear. This Mendelian Randomization (MR) study utilized GWAS data and IVW methods to investigate plasma lipids and PD risk. The genetic predispositions to altered levels of triacylglycerols (TAGs), diacylglycerols (DAGs), phosphatidylcholines (PCs), and phosphatidylethanolamines (PEs) are associated with an increased risk of PD, while the genetic predispositions to sphingomyelin (SM) and lysophosphatidylcholines (LPCs) are associated with a reduced risk of PD. Further research is needed to establish the biological mechanisms underlying these relationships.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.