N,N '，N″-三取代六氢-1,3,5-三嗪基单、二磷氨基酸的合成

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-04-28 DOI:10.1007/s11172-025-4573-y

Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin

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引用次数: 0

摘要

以1,3,5-[ω-（烷氧羰基）烷基]六氢-1,3,5-三嗪为基础，方便地合成了一、二磷氨基酸衍生物。PH酸与容易得到的六氢-1,3,5-三嗪和由此得到的n -取代双（烷氧甲基）胺反应，得到含有P(O)CH2NH和P(O)CH2NCH2P(O)单元的新的单磷和二磷取代氨基酸，以及甘氨酸、β-丙氨酸和γ-氨基丁酸残基。由此产生的化合物是有前途的生物活性物质，有效的萃取剂和水溶性多齿配体。

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N,N′,N″-Trisubstituted hexahydro-1,3,5-triazine-based synthesis of mono- and diphosphorus-containing amino acids

Convenient syntheses of mono- and diphosphorus-containing amino acid derivatives based on 1,3,5-[ω-(alkoxycarbonyl)alkyl]hexahydro-1,3,5-triazines have been developed. The reaction of PH acids with readily available hexahydro-1,3,5-triazines and N-substituted bis(alkoxymethyl)amines obtained therefrom gives new mono- and diphosphorus-substituted amino acids containing P(O)CH₂NH and P(O)CH₂NCH₂P(O) units together with glycine, β-alanine and γ-aminobutyric acid residues. The resulting compounds are of interest as promising biologically active substances, effective extractants, and water-soluble polydentate ligands.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.