路易斯酸催化重氮插入到缺电子的碳氢键

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2025-04-29 DOI:10.1007/s12039-025-02371-0

Jalaj Kumar Pathak, Namrata Rastogi

引用次数: 0

摘要

我们开发了一种将重氮化合物正式插入缺乏电子的1,3-二羰基化合物的C-H键的温和方案。路易斯酸催化的反应是通过重氮化合物的质子化，然后用二羰基底物亲核取代重氮- n2。该反应条件温和，底物范围广，产率高。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lewis acid-catalyzed diazo insertion into electron-deficient C–H bonds

We developed a mild protocol for the formal insertion of diazo compounds into the C–H bond of electron deficient 1,3-dicarbonyl compounds. The Lewis acid-catalyzed reaction proceeds through protonation of the diazo compound followed by nucleophilic substitution of diazo-N₂ with dicarbonyl substrate. The reaction is notable for its mild conditions, wide substrate scope and high yields of the products.

Graphical abstract

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.