胆道化生和巨噬细胞活化决定心源性肝病的细胞景观

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-04-01 DOI:10.1016/j.jacbts.2024.12.003

Arick C. Park MD, PhD , Christina F. Fu BS , Adeesh Parvathaneni BS , Bin Q. Yang MD , Mandy M. Chan BS , Kathleen Byrnes MD , Joel D. Schilling MD, PhD

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引用次数: 0

摘要

右心衰显著影响肝脏重塑和功能，这一过程被称为心源性肝病。虽然被认为是不良结果的危险因素，但对心力衰竭中导致肝脏疾病的细胞和分子因素知之甚少。利用心力衰竭患者的人类肝脏活检样本和肝脏充血的小鼠模型，我们揭示了巨噬细胞、肝星状细胞和胆道化生细胞之间的联系，这些细胞形成了心源性肝病的病理环境。

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Biliary Metaplasia and Macrophage Activation Define the Cellular Landscape of Cardiogenic Liver Disease

Right heart failure significantly impacts liver remodeling and function, a process referred to as cardiogenic liver disease. Although recognized as a risk factor for adverse outcomes, little is understood about the cellular and molecular players that contribute to liver disease in heart failure. Using human liver biopsy samples from patients with heart failure and a mouse model of liver congestion, we unraveled a nexus of macrophages, hepatic stellate cells, and biliary metaplastic cells that shape the pathologic environment of cardiogenic liver disease.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.