在日本样本中使用结构MRI的VBM分析评估与MMSE相关的局部脑区域

Q4 Neuroscience
Yoichi Sawada , Toru Satoh , Hideaki Saba , Yoshiki Kato , Tomoko Kuwada , Sayoko Shima , Kana Murakami , Megumi Sasaki , Yudai Abe , Kaori Harano
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引用次数: 0

摘要

全球人口老龄化导致痴呆症和认知能力下降显著上升,阿尔茨海默病是主要原因。早期发现轻度认知障碍(MCI)是痴呆的前驱阶段,对及时干预至关重要。迷你精神状态检查(MMSE)通常用于认知筛查,但其局限性——如天花板效应和教育偏见——可能会阻碍早期识别细微的认知障碍。这项横断面研究采用基于体素的形态测量(VBM)分析结构磁共振成像(MRI)来探索与MMSE评分正相关的大脑区域,共有510名参与者。在MMSE评分较低的患者中,双侧外侧额叶、左侧内侧额叶、左侧海马、左侧前扣带皮层(ACC)和双侧颞下回的灰质体积(GMV)显著减少。参与者根据MMSE截止值分为正常认知(NC)、MCI和痴呆(D)三组。与NC组相比,MCI组在左侧海马、左侧海马旁回、左侧ACC和右侧腹内侧前额叶皮质(vmPFC)中表现出显著的GMV减少。与MCI组相比,D组双侧海马和左侧颞下回GMV进一步降低。这些发现强调了基于vbm的结构MRI在评估与认知能力下降相关的局部脑萎缩方面的临床应用,支持了其在MCI早期诊断和干预中的潜在作用。进一步的研究整合纵向研究和多模态生物标志物是必要的,以提高诊断的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample
The global aging population has led to a significant rise in dementia and cognitive decline, with Alzheimer's disease as the primary cause. Early detection of mild cognitive impairment (MCI), a prodromal stage of dementia, is critical for timely intervention. The Mini-Mental State Examination (MMSE) is commonly used for cognitive screening, yet its limitations—such as ceiling effects and educational biases—may hinder the early identification of subtle cognitive impairments. This cross-sectional study employed voxel-based morphometry (VBM) analysis of structural magnetic resonance imaging (MRI) to explore brain regions positively correlated with MMSE scores in a cohort of 510 participants. Significant gray matter volume (GMV) reductions were observed in the bilateral lateral frontal lobes, left medial frontal lobe, left hippocampus, left anterior cingulate cortex (ACC), and bilateral inferior temporal gyri in association with lower MMSE scores. Participants were classified into three groups—Normal Cognition (NC), MCI, and Dementia (D)—based on MMSE cutoff values. Compared to the NC group, the MCI group exhibited significant GMV reductions in the left hippocampus, left parahippocampal gyrus, left ACC, and right ventromedial prefrontal cortex (vmPFC). The D group showed further GMV reductions in the bilateral hippocampus and left inferior temporal gyrus compared to the MCI group. These findings highlight the clinical utility of VBM-based structural MRI in assessing localized brain atrophy associated with cognitive decline, supporting its potential role in early diagnosis and intervention for MCI. Further research integrating longitudinal studies and multimodal biomarkers is warranted to enhance diagnostic accuracy.
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来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
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0.00%
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审稿时长
87 days
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