Remediation of antibiotic pollution in the global environment by iron-based materials activating advanced oxidation processes: A systematic review

Antibiotic pollution and its associated resistance genes have emerged as a global environmental and health concern, with widespread detection in various environmental media such as water, soil, atmosphere, and sediment, as well as in organisms. Hence, it is imperative to develop effective remediation technologies for the targeted treatment of antibiotic pollution to mitigate its environmental and health risks. This paper reviews the status of antibiotic pollution in major countries, territories, and regions worldwide. Addressing the risks cause by antibiotics and their resistance genes and achieving efficient remediation of antibiotic pollutants. Additionally, the study explores the issue of antibiotic use and resistance in detail from a global perspective. It provides a critical scientific foundation for controlling global antibiotic resistance through multi-dimensional integrated analysis. In 2021, 4.71 million deaths globally were attributed to antibiotic resistance, with countries such as India and China being the most affected. It also examined the predominant types and sources of antibiotic pollutants, as well as key remediation technologies for addressing antibiotic contamination. Antibiotics such as amoxicillin and ciprofloxacin are commonly found in surface waters at concentrations ranging from 1 to 120 μg L⁻¹. Furthermore, this paper highlighted the distinctive advantages of advanced oxidation processes (AOPs) in addressing antibiotic pollution, demonstrating removal efficiencies exceeding 90 % under optimal conditions. Our review underscored the pivotal role of iron-based materials and porous biochar in AOPs, showing promising results in various environmental settings. Future research should prioritize the development of multifunctional iron-based composites with improved catalytic stability, environmental compatibility, and recyclability. Moreover, expanding the field-scale application of these materials, particularly in low-resource or high-risk regions, will be essential to translate laboratory successes into global impact. This analysis is designed to inform and guide future initiatives to control and eliminate antibiotic contamination.