评估全身靶向抗癌治疗眼部副作用的临床和影像学策略

IF 7.6 1区医学 Q1 ONCOLOGY

European Journal of Cancer Pub Date : 2025-04-22 DOI:10.1016/j.ejca.2025.115452

Luke Michaels , Maha Noor , Tariq Aslam

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引用次数: 0

摘要

系统性靶向抗癌疗法选择性地靶向癌细胞，同时限制全身副作用。然而，眼睛是一个特别敏感的器官，新的靶向化疗药物的广泛使用与多种眼部副作用有关。在这篇综述中，我们提供了新的靶向化疗药物的眼部副作用的最新情况，以及建议的最小的、实用的、基于证据的有效筛查或监测潜在眼部副作用的策略。该框架旨在指导肿瘤学家、试验管理人员、方案开发人员和监管机构，以便根据患者的具体治疗要求和委托进行适当的眼科临床检查和非侵入性现代成像。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical and imaging strategies for the assessment of the ocular side effects of systemic targeted anti-cancer therapies

Systemic targeted anti-cancer therapies selectively target cancerous cells whilst limiting systemic side effects. The eye however, is a particularly sensitive organ and the expanding use of the newer targeted chemotherapy agents has been associated with multiple ocular side effects. In this review we provide an update of the ocular side effects of the newer targeted chemotherapy agents along with suggested minimum, pragmatic, evidence-based strategies for effective screening or monitoring for potential ocular side effects. This framework is designed to guide oncologists, trial managers, protocol developers and regulatory authorities so that appropriate ophthalmic clinical examinations and non-invasive modern imaging can be requested and commissioned according to a patient’s specific treatment.

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来源期刊

European Journal of Cancer 医学-肿瘤学

CiteScore

11.50

自引率

4.80%

发文量

953

审稿时长

23 days

期刊介绍： The European Journal of Cancer (EJC) serves as a comprehensive platform integrating preclinical, digital, translational, and clinical research across the spectrum of cancer. From epidemiology, carcinogenesis, and biology to groundbreaking innovations in cancer treatment and patient care, the journal covers a wide array of topics. We publish original research, reviews, previews, editorial comments, and correspondence, fostering dialogue and advancement in the fight against cancer. Join us in our mission to drive progress and improve outcomes in cancer research and patient care.