{"title":"自供电热电水凝胶加速伤口愈合","authors":"Yuandong Qin, Shiyu Jia, Xiao-Lei Shi, Shaojingya Gao*, Jiangqi Zhao, Huangshui Ma, Yanxing Wei, Qinlin Huang, Lei Yang, Zhi-Gang Chen* and Qiang Sun*, ","doi":"10.1021/acsnano.5c0174210.1021/acsnano.5c01742","DOIUrl":null,"url":null,"abstract":"<p >Electrical stimulation (ES) serves as a biological cue that regulates critical cellular processes, including proliferation and migration, offering an effective approach to accelerating wound healing. Thermoelectrics, capable of generating electricity by exploiting the temperature difference between skin and the surrounding environment without external energy input, present a promising avenue for ES-based therapies. Herein, we developed Ag<sub>2</sub>Se@gelatin methacrylate (Ag<sub>2</sub>Se@GelMA) thermoelectric hydrogels with high room-temperature thermoelectric performance and employed them as self-powered ES devices for wound repair. Systematic <i>in vivo</i> and <i>in vitro</i> investigations elucidated their biological mechanisms for enhancing wound healing. Our findings reveal that the Ag<sub>2</sub>Se@GelMA thermoelectric hydrogels can significantly accelerate the wound closure by amplifying the endogenous electric field, thereby promoting cell proliferation, migration, and angiogenesis. Comprehensive <i>in vitro</i> experiments demonstrated that ES generated by the hydrogels activates voltage-gated calcium ion channels, elevating intracellular Ca<sup>2+</sup> levels and enhancing mitochondrial functions through the Ca<sup>2+</sup>/CaMKKβ/AMPK/Nrf2 pathway. This cascade improves mitochondrial dynamics and angiogenesis, thereby accelerating tissue regeneration. The newly developed Ag<sub>2</sub>Se@GelMA thermoelectric hydrogels represent a marked progress in wound dressing technology with the potential to improve clinical strategies in tissue engineering and regenerative medicine.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"19 16","pages":"15924–15940 15924–15940"},"PeriodicalIF":16.0000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Self-Powered Thermoelectric Hydrogels Accelerate Wound Healing\",\"authors\":\"Yuandong Qin, Shiyu Jia, Xiao-Lei Shi, Shaojingya Gao*, Jiangqi Zhao, Huangshui Ma, Yanxing Wei, Qinlin Huang, Lei Yang, Zhi-Gang Chen* and Qiang Sun*, \",\"doi\":\"10.1021/acsnano.5c0174210.1021/acsnano.5c01742\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Electrical stimulation (ES) serves as a biological cue that regulates critical cellular processes, including proliferation and migration, offering an effective approach to accelerating wound healing. Thermoelectrics, capable of generating electricity by exploiting the temperature difference between skin and the surrounding environment without external energy input, present a promising avenue for ES-based therapies. Herein, we developed Ag<sub>2</sub>Se@gelatin methacrylate (Ag<sub>2</sub>Se@GelMA) thermoelectric hydrogels with high room-temperature thermoelectric performance and employed them as self-powered ES devices for wound repair. Systematic <i>in vivo</i> and <i>in vitro</i> investigations elucidated their biological mechanisms for enhancing wound healing. Our findings reveal that the Ag<sub>2</sub>Se@GelMA thermoelectric hydrogels can significantly accelerate the wound closure by amplifying the endogenous electric field, thereby promoting cell proliferation, migration, and angiogenesis. Comprehensive <i>in vitro</i> experiments demonstrated that ES generated by the hydrogels activates voltage-gated calcium ion channels, elevating intracellular Ca<sup>2+</sup> levels and enhancing mitochondrial functions through the Ca<sup>2+</sup>/CaMKKβ/AMPK/Nrf2 pathway. This cascade improves mitochondrial dynamics and angiogenesis, thereby accelerating tissue regeneration. The newly developed Ag<sub>2</sub>Se@GelMA thermoelectric hydrogels represent a marked progress in wound dressing technology with the potential to improve clinical strategies in tissue engineering and regenerative medicine.</p>\",\"PeriodicalId\":21,\"journal\":{\"name\":\"ACS Nano\",\"volume\":\"19 16\",\"pages\":\"15924–15940 15924–15940\"},\"PeriodicalIF\":16.0000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Nano\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsnano.5c01742\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Nano","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsnano.5c01742","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Electrical stimulation (ES) serves as a biological cue that regulates critical cellular processes, including proliferation and migration, offering an effective approach to accelerating wound healing. Thermoelectrics, capable of generating electricity by exploiting the temperature difference between skin and the surrounding environment without external energy input, present a promising avenue for ES-based therapies. Herein, we developed Ag2Se@gelatin methacrylate (Ag2Se@GelMA) thermoelectric hydrogels with high room-temperature thermoelectric performance and employed them as self-powered ES devices for wound repair. Systematic in vivo and in vitro investigations elucidated their biological mechanisms for enhancing wound healing. Our findings reveal that the Ag2Se@GelMA thermoelectric hydrogels can significantly accelerate the wound closure by amplifying the endogenous electric field, thereby promoting cell proliferation, migration, and angiogenesis. Comprehensive in vitro experiments demonstrated that ES generated by the hydrogels activates voltage-gated calcium ion channels, elevating intracellular Ca2+ levels and enhancing mitochondrial functions through the Ca2+/CaMKKβ/AMPK/Nrf2 pathway. This cascade improves mitochondrial dynamics and angiogenesis, thereby accelerating tissue regeneration. The newly developed Ag2Se@GelMA thermoelectric hydrogels represent a marked progress in wound dressing technology with the potential to improve clinical strategies in tissue engineering and regenerative medicine.
期刊介绍:
ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.