自供电热电水凝胶加速伤口愈合

IF 16 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Yuandong Qin, Shiyu Jia, Xiao-Lei Shi, Shaojingya Gao*, Jiangqi Zhao, Huangshui Ma, Yanxing Wei, Qinlin Huang, Lei Yang, Zhi-Gang Chen* and Qiang Sun*, 
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引用次数: 0

摘要

电刺激(ES)作为一种生物线索,调节关键的细胞过程,包括增殖和迁移,为加速伤口愈合提供了有效的方法。热电技术能够在没有外部能量输入的情况下利用皮肤和周围环境之间的温差发电,为基于es的治疗提供了一条有前途的途径。在此,我们开发了具有高室温热电性能的Ag2Se@gelatin甲基丙烯酸酯(Ag2Se@GelMA)热电水凝胶,并将其用作伤口修复的自供电ES装置。系统的体内和体外研究阐明了它们促进伤口愈合的生物学机制。我们的研究结果表明Ag2Se@GelMA热电水凝胶可以通过放大内源电场显著加速伤口愈合,从而促进细胞增殖、迁移和血管生成。综合体外实验表明,由水凝胶产生的ES激活电压门控钙离子通道,通过Ca2+/CaMKKβ/AMPK/Nrf2途径提高细胞内Ca2+水平,增强线粒体功能。这个级联改善线粒体动力学和血管生成,从而加速组织再生。新开发的Ag2Se@GelMA热电水凝胶代表了伤口敷料技术的显著进步,具有改善组织工程和再生医学临床策略的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Self-Powered Thermoelectric Hydrogels Accelerate Wound Healing

Self-Powered Thermoelectric Hydrogels Accelerate Wound Healing

Electrical stimulation (ES) serves as a biological cue that regulates critical cellular processes, including proliferation and migration, offering an effective approach to accelerating wound healing. Thermoelectrics, capable of generating electricity by exploiting the temperature difference between skin and the surrounding environment without external energy input, present a promising avenue for ES-based therapies. Herein, we developed Ag2Se@gelatin methacrylate (Ag2Se@GelMA) thermoelectric hydrogels with high room-temperature thermoelectric performance and employed them as self-powered ES devices for wound repair. Systematic in vivo and in vitro investigations elucidated their biological mechanisms for enhancing wound healing. Our findings reveal that the Ag2Se@GelMA thermoelectric hydrogels can significantly accelerate the wound closure by amplifying the endogenous electric field, thereby promoting cell proliferation, migration, and angiogenesis. Comprehensive in vitro experiments demonstrated that ES generated by the hydrogels activates voltage-gated calcium ion channels, elevating intracellular Ca2+ levels and enhancing mitochondrial functions through the Ca2+/CaMKKβ/AMPK/Nrf2 pathway. This cascade improves mitochondrial dynamics and angiogenesis, thereby accelerating tissue regeneration. The newly developed Ag2Se@GelMA thermoelectric hydrogels represent a marked progress in wound dressing technology with the potential to improve clinical strategies in tissue engineering and regenerative medicine.

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来源期刊
ACS Nano
ACS Nano 工程技术-材料科学:综合
CiteScore
26.00
自引率
4.10%
发文量
1627
审稿时长
1.7 months
期刊介绍: ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.
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