镁掺杂碳点纳米酶作为抗菌和抗炎剂的光切换抗氧化和促氧化活性

IF 8.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Jinyu Shi, Yu Zhang, Xiangyang Fang, Xing Fan, Jing Li, Chuan-Hua Zhou, Zhining Xia, Dai-Wen Pang, Cui Liu
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引用次数: 0

摘要

多酶纳米酶具有较高的催化效率和多功能性,在治疗领域具有很大的潜力。然而,在同一病变中灵活切换多酶纳米酶的抗氧化和促氧化活性仍然是一个挑战。在此,我们设计了在生理条件下具有光切换抗氧化和促氧化活性的镁掺杂碳点(Mg-CD)纳米酶。Mg-CD纳米酶具有超氧化物歧化酶(SOD)样活性,可以在不光照的情况下清除单线态氧和羟基自由基。有趣的是,在可见光照射下,抗氧化活性可以转化为类似氧化酶的活性,产生单线态氧和超氧阴离子。镁与CD骨架的配合增强了单重态的激发态电子转移和三重态电子的能量转移。因此,mg - cd可以作为抗菌和抗炎剂。Mg-CDs在光照下5分钟内抗菌率超过99%。它们可以清除活性氧,因此在治疗脂多糖引起的炎症性伤口方面表现出优异的能力。CD纳米酶的这些光切换抗氧化和促氧化活性为更好地操纵纳米酶的多功能性,扩大其智能生物医学应用提供了有效的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Photoswitchable Antioxidant and Prooxidant Activities of Mg-Doped Carbon Dot Nanozymes as Antibacterial and Anti-Inflammatory Agents

Photoswitchable Antioxidant and Prooxidant Activities of Mg-Doped Carbon Dot Nanozymes as Antibacterial and Anti-Inflammatory Agents
Multienzymatic nanozymes hold great potential in therapeutics due to their higher catalytic efficiency and multifunctionality. However, flexibly switching the antioxidant and prooxidant activities of multienzymic nanozymes at the same lesion remains a challenge. Herein, we design magnesium-doped carbon dot (Mg-CD) nanozymes with photoswitchable antioxidant and prooxidant activities under physiological conditions. The Mg-CD nanozymes exhibit superoxide dismutase (SOD)-like activity and can scavenge singlet oxygen and hydroxyl radicals without illumination. Interestingly, the antioxidant activity can be converted to oxidase-like activity under visible light illumination, producing singlet oxygen and superoxide anions. The mechanism of the switchable activities is attributed to the fact that coordination between magnesium and the CD skeleton enhances the excited-state electron transfer of singlet states and the energy transfer of triplet electrons. Therefore, Mg-CDs can act as antibacterial and anti-inflammatory agents. Mg-CDs exhibit antibacterial rates exceeding 99% within 5 min under illumination. They can scavenge reactive oxygen species, thereby showing excellent capacity in treating inflammatory wounds caused by lipopolysaccharide. These photoswitchable antioxidant and prooxidant activities of CD nanozymes offer an effective strategy for better manipulating the versatility of nanozymes, expanding their intelligent biomedical applications.
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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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