在刺激性癫痫细胞模型中使用荧光探针可视化臭氧波动

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-28 DOI:10.1039/d4cc06310d

Jian Zhang, Yu Duan, Chang Liu, Mingyue Zhang, Heng Liu, Xingchen Ming, Yong Li, Xiaoyun Jiao, Xu Wang, Bo Tang

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引用次数: 0

摘要

BID-Ozo是一种专门用于检测内源性臭氧（O₃）的线粒体靶向荧光探针。用高浓度谷氨酸（Glu）刺激PC12细胞，观察到细胞内O₃显著增加。

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Visualizing ozone fluctuations employing a fluorescent probe in stimulated-epilepsy cell models

BID-Ozo, a mitochondrial-targeted fluorescence probe specifically designed to detect endogenous ozone (O₃) was developed. A significant increase in intracellular O₃ was observed in PC12 cells stimulated with high concentrations of glutamate (Glu), which is used to model epilepsy.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.