缺氧触发单线态氧氮芥释放的协同治疗作用

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-28 DOI:10.1039/d5cc00390c

Yuan Qiao, yun nie, Yu Si, Xiao Qian, Yingxu Wu, Tingting Zhang, Bing Liu, Lei Wang, Engin Akkaya, Zhihao Chen

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引用次数: 0

摘要

我们报道了一种内过氧化物和氮芥缀合物（Pyd-endo）作为前药，可以在缺氧条件下释放细胞毒性单线态氧和芳香氮芥。细胞培养实验表明，前药具有缺氧反应性，能够杀死和抑制多种类型癌细胞的迁移和增殖。对荷瘤小鼠和脂质体制剂的研究也证明了其在体内的抗癌作用。我们的设计，不仅解决了肿瘤缺氧和PDT有限的光穿透问题的挑战，而且还展示了单线态氧和化疗药物联合细胞毒性作用的力量

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hypoxia-Triggered Singlet Oxygen and Nitrogen Mustard Release Towards a Synergistic Therapeutic Action

We report an endoperoxide and nitrogen mustard conjugate (Pyd-endo) as a prodrug which can release cytotoxic singlet oxygen and aromatic nitrogen mustard under hypoxic conditions. Cell culture experiments demonstrated the hypoxia-responsiveness of prodrug and its ability to kill and inhibit the migration and proliferation of various types of cancer cells. Studies using tumor-bearing mice also and a liposomal formulation demonstrated its anticancer utility in vivo. Our design, not only addresses the challenges of tumor hypoxia and limited light penetration issues of PDT, but also present the power of combined cytotoxic action of singlet oxygen and a chemotherapy agent

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.