银催化的杜鹃酸与脂肪羧酸直接脱羧甲基化反应

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-04-23 DOI:10.1016/j.tetlet.2025.155619

Jie Zeng , Houwen Zhou , Shenghao Wang , Fenghua Zhang , Fei Li , Jingjing Wang , Lin Li , Tianbao Dong , Mingyue Cui , Feng Li

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引用次数: 0

摘要

我们提出了一种新的方法，以脂肪族羧酸为烷基自由基前体，在银的催化下，将杜鹃酸烷基化。该技术标志着有机合成领域的重大进展，为氮脲基修饰提供了一条灵活有效的途径。该方法已成功地应用于多种一级、二级和三级羧酸，突出了其广泛的实用性和可靠性。该方法的适用性允许制备一系列烷基化的杜鹃酸衍生物，这些衍生物是创造新药，农用化学品和材料的潜在中间体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Silver-catalyzed direct decarboxylative CH functionalization of azauracils with aliphatic carboxylic acids

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Silver-catalyzed direct decarboxylative CH functionalization of azauracils with aliphatic carboxylic acids

We propose a novel method for the CH alkylation of azauracils using aliphatic carboxylic acids as alkyl radical precursors, catalyzed by silver. This technique marks a substantial progress in organic synthesis, providing a flexible and effective route for azauracils modification. The method has been successfully applied to a diverse array of primary, secondary and tertiary carboxylic acids, highlighting its broad utility and reliability. The applicability of this method allows the preparation of a range of alkylated azauracil derivatives, which are potential intermediates for the creation of new pharmaceuticals, agrochemicals, and materials.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.