炎症和少数民族压力：有调节的童年逆境和男男性行为青年心理健康中介模型

IF 4.9 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Social Science & Medicine Pub Date : 2025-04-23 DOI:10.1016/j.socscimed.2025.118119

Laura H. Dosanjh , Cynthia Franklin , Yessenia Castro , Bridget Goosby , Fiona N. Conway , Frances A. Champagne , Luis A. Parra , Jeremy T. Goldbach , Michele D. Kipke

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引用次数: 0

摘要

不良的童年经历（ace）与后来的焦虑和抑郁有关，炎症被认为是一种中介机制。与异性恋白人男性相比，与男性发生性关系的黑人和拉丁裔男性（MSM）面临着更高的ace、焦虑和抑郁患病率。了解不良经历和心理健康之间的联系对于解决这些差异至关重要。方法本研究采用结构方程模型对调节的中介模型进行检验，检验炎症在ace与焦虑/抑郁症状之间的中介作用，少数民族应激在ace与炎症之间的调节作用。数据来自黑人和拉丁裔MSM社区样本(n = 246；平均年龄= 22.6)。结果saces与焦虑症状显著相关(B = 0.414；p & lt;0.001)和抑郁(B = 0.346；p & lt;0.001)，但炎症没有表现出显著的中介作用。此外，ace与少数民族应激之间的交互作用对焦虑/抑郁没有显著的间接影响。结论：这些发现强调了炎症可能并不代表年轻ace后应激过程的全局扰动，特别是在相对健康的新生成人样本中。

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Inflammation and minority stress: A moderated mediation model of childhood adversity and mental health in young men who have sex with men

Rationale

Adverse childhood experiences (ACEs) are linked to later anxiety and depression, and inflammation has been implicated as a mediating mechanism. Black and Latinx men who have sex with men (MSM) face higher prevalences of ACEs, anxiety, and depression compared to White, heterosexual peers. Understanding the links between ACEs and mental health is crucial to addressing these disparities.

Methods

This study used structural equation modeling to test moderated mediation models examining inflammation as a mediator of the relationship between ACEs and symptoms of anxiety/depression and minority stress as a moderator on the path between ACEs and inflammation. Data was from a community sample of Black and Latinx MSM (n = 246; mean age = 22.6).

Results

ACEs were significantly associated with symptoms of anxiety (B = 0.414; p < 0.001) and depression (B = 0.346; p < 0.001), but inflammation did not show a significant mediating effect. Additionally, the interaction between ACEs and minority stress had no significant indirect effect on anxiety/depression.

Conclusions

These findings underscore the possibility that inflammation may not represent the global perturbations of stress processes after ACEs at younger ages, particularly among a relatively healthy sample of emerging adults.

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来源期刊

Social Science & Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

9.10

自引率

5.60%

发文量

762

审稿时长

38 days

期刊介绍： Social Science & Medicine provides an international and interdisciplinary forum for the dissemination of social science research on health. We publish original research articles (both empirical and theoretical), reviews, position papers and commentaries on health issues, to inform current research, policy and practice in all areas of common interest to social scientists, health practitioners, and policy makers. The journal publishes material relevant to any aspect of health from a wide range of social science disciplines (anthropology, economics, epidemiology, geography, policy, psychology, and sociology), and material relevant to the social sciences from any of the professions concerned with physical and mental health, health care, clinical practice, and health policy and organization. We encourage material which is of general interest to an international readership.