芳香阴离子载体与咪唑融合芳香两亲体的自组装

Precision Chemistry Pub Date : 2024-12-18 DOI:10.1021/prechem.4c0007410.1021/prechem.4c00074

Jung Yeon Park, Dongjun Baek, Hyunggeun Min, Bongjun Yeom, Jeong Sook Ha and Yongju Kim*,

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引用次数: 0

摘要

由于细胞膜的外表面带负电荷，阴离子在细胞膜上的运输是困难的。为了克服这一限制，在这里，我们报告了一个系统，通过自组装通过细胞膜运输芳香族阴离子使用合成咪唑融合芳香两亲体。阳离子基和芳基相互靠近的两亲体可以通过静电和芳相互作用与阴离子吡啶相互作用，形成超分子囊泡。基于合成咪唑融合芳香两亲体和吡喃复合物的超分子囊泡在活的MCF-7细胞膜上运输阴离子芳香吡喃而无细胞毒性。

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Aromatic Anion Carrier via Self-Assembly with Imidazolium-Fused Aromatic Amphiphiles

The transport of anions across cell membranes is difficult because of the negatively charged outer surfaces of cell membranes. To overcome this limitation, herein, we report a system for transporting aromatic anions across cellular membranes via self-assembly using a synthetic imidazolium-fused aromatic amphiphile. The amphiphile with cationic and aromatic groups in close proximity to each other could interact with anionic pyranine via electrostatic and aromatic interactions to form supramolecular vesicles. Supramolecular vesicles based on the synthetic imidazolium-fused aromatic amphiphile and pyranine complex transport anionic aromatic pyranine across the membranes of live MCF-7 cells without cytotoxicity.

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来源期刊

Precision Chemistry 精密化学技术-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Chemical research focused on precision enables more controllable predictable and accurate outcomes which in turn drive innovation in measurement science sustainable materials information materials personalized medicines energy environmental science and countless other fields requiring chemical insights.Precision Chemistry provides a unique and highly focused publishing venue for fundamental applied and interdisciplinary research aiming to achieve precision calculation design synthesis manipulation measurement and manufacturing. It is committed to bringing together researchers from across the chemical sciences and the related scientific areas to showcase original research and critical reviews of exceptional quality significance and interest to the broad chemistry and scientific community.