一种高效的近红外荧光抑制剂可同时诱导三阴性乳腺癌细胞凋亡和抑制转移

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-04-17 DOI:10.1016/j.saa.2025.126183

Qixin Zhao , Jiao Wu , Jiale Yao , Zengjin Liu , Changqiang Li , Qin Sun

{"title":"一种高效的近红外荧光抑制剂可同时诱导三阴性乳腺癌细胞凋亡和抑制转移","authors":"Qixin Zhao , Jiao Wu , Jiale Yao , Zengjin Liu , Changqiang Li , Qin Sun","doi":"10.1016/j.saa.2025.126183","DOIUrl":null,"url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) is a cancerous tumor that poses a global threat to women’s lives and health. Currently, chemotherapy is the preferred treatment for advanced TNBC. In this work, we have identified a novel NIR fluorescent inhibitor, SWMU690, which can effectively inhibit the proliferation of TNBC at low doses. The half-maximal inhibitory concentration (IC<sub>50</sub>) values of SWMU690 against the MDA-MB-231, 4 T1, and T47D cell lines were determined to be 104 nM, 509.4 nM, and 206 nM, respectively. We found that SWMU690 specifically localized in mitochondria to trigger mitochondria-mediated intrinsic apoptotic pathways. Furthermore, SWMU690 can suppress the production of ATP to inhibit TNBC metastasis. This study demonstrated the advantage of disrupting the function of mitochondria in inhibiting the proliferation and metastasis of TNBC, and may have other applications in the treatment of other malignant tumors.</div></div>","PeriodicalId":433,"journal":{"name":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","volume":"339 ","pages":"Article 126183"},"PeriodicalIF":4.3000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor\",\"authors\":\"Qixin Zhao , Jiao Wu , Jiale Yao , Zengjin Liu , Changqiang Li , Qin Sun\",\"doi\":\"10.1016/j.saa.2025.126183\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Triple-negative breast cancer (TNBC) is a cancerous tumor that poses a global threat to women’s lives and health. Currently, chemotherapy is the preferred treatment for advanced TNBC. In this work, we have identified a novel NIR fluorescent inhibitor, SWMU690, which can effectively inhibit the proliferation of TNBC at low doses. The half-maximal inhibitory concentration (IC<sub>50</sub>) values of SWMU690 against the MDA-MB-231, 4 T1, and T47D cell lines were determined to be 104 nM, 509.4 nM, and 206 nM, respectively. We found that SWMU690 specifically localized in mitochondria to trigger mitochondria-mediated intrinsic apoptotic pathways. Furthermore, SWMU690 can suppress the production of ATP to inhibit TNBC metastasis. This study demonstrated the advantage of disrupting the function of mitochondria in inhibiting the proliferation and metastasis of TNBC, and may have other applications in the treatment of other malignant tumors.</div></div>\",\"PeriodicalId\":433,\"journal\":{\"name\":\"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy\",\"volume\":\"339 \",\"pages\":\"Article 126183\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1386142525004895\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SPECTROSCOPY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1386142525004895","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SPECTROSCOPY","Score":null,"Total":0}

引用次数: 0

摘要

三阴性乳腺癌（TNBC）是一种癌症肿瘤，对妇女的生命和健康构成全球性威胁。目前，化疗是晚期TNBC的首选治疗方法。在这项工作中，我们鉴定了一种新的近红外荧光抑制剂SWMU690，它可以在低剂量下有效抑制TNBC的增殖。SWMU690对MDA-MB-231、4 T1和T47D细胞株的半最大抑制浓度（IC50）值分别为104 nM、509.4 nM和206 nM。我们发现SWMU690特异性定位于线粒体，触发线粒体介导的内在凋亡途径。此外，SWMU690可以抑制ATP的产生，从而抑制TNBC的转移。本研究证明了破坏线粒体功能在抑制TNBC增殖和转移中的优势，并可能在其他恶性肿瘤的治疗中有其他应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor

查看原文本刊更多论文

Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor

Triple-negative breast cancer (TNBC) is a cancerous tumor that poses a global threat to women’s lives and health. Currently, chemotherapy is the preferred treatment for advanced TNBC. In this work, we have identified a novel NIR fluorescent inhibitor, SWMU690, which can effectively inhibit the proliferation of TNBC at low doses. The half-maximal inhibitory concentration (IC₅₀) values of SWMU690 against the MDA-MB-231, 4 T1, and T47D cell lines were determined to be 104 nM, 509.4 nM, and 206 nM, respectively. We found that SWMU690 specifically localized in mitochondria to trigger mitochondria-mediated intrinsic apoptotic pathways. Furthermore, SWMU690 can suppress the production of ATP to inhibit TNBC metastasis. This study demonstrated the advantage of disrupting the function of mitochondria in inhibiting the proliferation and metastasis of TNBC, and may have other applications in the treatment of other malignant tumors.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.