自组装融合疏水性涂层纳米金刚石系统协同靶向治疗结直肠癌

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-26 DOI:10.1039/d5cc00919g

Haotian Li, Yupeng Wang, Hui Qiao, Fengming Liu, Zhuoyu Li, Han Zhiqiang, Zhihua Guo, Yingqi Li, Mingqiang Qiao

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引用次数: 0

摘要

一种新型纳米平台（GE11-HGFI@ND-DOX）能够特异性靶向结直肠癌高表达EGFR受体HCT-116细胞，阐明精确靶向和强化治疗，同时增强其分散性和亲水性。这项工作为整合疏水蛋白和纳米金刚石封装给药系统的协同靶向治疗的发展开辟了前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Self-assembled Fusion Hydrophobins-Coated Nanodiamond System for Synergistic Targeted Therapy of Colorectal Cancer

A novel nano-platform (GE11-HGFI@ND-DOX) capable of specifically targeting Colorectal Cancer HCT-116 cells with high expressed EGFR receptors, illuminating precise targeting and enhanced therapy, while enhancing its dispersivity and hydrophilicity. This work opens up prospects for development of synergistic targeted therapy by integrating hydrophobins and nanodiamond encapsulated drug delivery systems.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.