PLGA-PEG-PLGA聚合物:从合成到先进的制药应用

IF 2 4区 工程技术 Q3 ENGINEERING, CHEMICAL
Bartosz Strus, Arkadiusz Szterk
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引用次数: 0

摘要

本文对PLGA-PEG-PLGA聚合物进行了深入分析,重点介绍了其合成及其在先进给药系统(dds)中的应用。PLGA-PEG-PLGA是一种三嵌段共聚物,由于其生物可降解性、生物相容性和热敏性而受到关注,使其适用于包封亲水性和疏水性化合物。该聚合物具有在体温下从溶胶到凝胶的能力,可以控制和靶向药物释放,显著提高了紫杉醇和伊立替康等难溶性药物的溶解度。本文讨论了开环聚合(ROP)合成聚合物的方法,并利用微波辅助技术和超临界CO2等方法对其进行了优化。此外,它还在体外和体内研究中检查了聚合物的细胞毒性,强调了它的低毒性和更有效地递送化疗药物的能力。这项研究强调了这种聚合物在癌症治疗、生物制药输送和开发双敏感药物载体方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

PLGA-PEG-PLGA Polymer: From Synthesis to Advanced Pharmaceutical Applications

PLGA-PEG-PLGA Polymer: From Synthesis to Advanced Pharmaceutical Applications

This paper presents an in-depth analysis of the PLGA-PEG-PLGA polymer, focusing on its synthesis and applications in advanced drug delivery systems (DDSs). PLGA-PEG-PLGA, a triblock copolymer, gains attention due to its biodegradability, biocompatibility, and thermosensitive properties, making it suitable for encapsulating both hydrophilic and hydrophobic compounds. The polymer’s ability to undergo sol-to-gel at body temperature allows controlled and targeted drug release, significantly enhancing the solubility of poorly soluble drugs, such as paclitaxel and irinotecan. The paper discusses the polymer’s synthesis via ring-opening polymerization (ROP) and explores its optimization using various methods, including microwave-assisted techniques and supercritical CO2. Additionally, it examines the polymer’s cytotoxicity in in vitro and in vivo studies, emphasizing its low toxicity and ability to deliver chemotherapeutic agents more effectively. The study highlights the polymer’s potential in cancer therapy, biopharmaceutical delivery, and the development of dual-sensitive drug carriers.

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来源期刊
Advances in Polymer Technology
Advances in Polymer Technology 工程技术-高分子科学
CiteScore
5.50
自引率
0.00%
发文量
70
审稿时长
9 months
期刊介绍: Advances in Polymer Technology publishes articles reporting important developments in polymeric materials, their manufacture and processing, and polymer product design, as well as those considering the economic and environmental impacts of polymer technology. The journal primarily caters to researchers, technologists, engineers, consultants, and production personnel.
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