趋化因子受体5信号在口腔疾病和退行性颞下颌关节疾病中的作用

IF 2.6 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Biosciences Pub Date : 2025-04-24 DOI:10.1016/j.job.2025.100666

Haruhisa Watanabe , Riyu Koguchi , Takashi S. Kajii , Yutaka Maruoka , Tadahiro Iimura

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引用次数: 0

摘要

趋化因子受体5 （CCR5）介导的信号参与多种生物反应和炎症性疾病。近年来的研究揭示了该信号通路在骨代谢、代谢性骨病和关节疾病中的作用。通过临床前和临床研究，本课课组已证实CCR5信号通路深度参与颞下颌关节（TMJ）退行性改变。在这篇简短的综述中，我们概述了CCR5信号在口腔和退行性TMJ疾病中的多种功能。

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Chemokine receptor 5 signaling in oral diseases and degenerative temporomandibular joint disease

Background

Chemokine receptor 5 (CCR5)-mediated signals are involved in various biological responses and inflammatory diseases. Recent studies have revealed the roles of this signaling pathway in bone metabolism, metabolic bone diseases, and joint diseases.

Highlight

Through preclinical and clinical studies, our research group has demonstrated that CCR5 signaling is deeply involved in degenerative changes in the temporomandibular joint (TMJ).